Results 131 to 140 of about 1,231,981 (407)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Ethical dilemmas experienced by nurses in providing care for critically ill patients in intensive care units, Medan, Indonesia

Journal of Health Science and Medical Research (JHSMR), 2004
The purpose of this hermeneutic phenomenological study was to describe ethical dilemmas experienced by nurses in providing care for critically ill patients in intensive care units in Medan, Indonesia.
Setiawan Setiawan, A Chaowalit, W Suttharangsee   +2 more
doaj  

Relation between Hydration Status and Cognitive Function among Critically Ill Patients

Evidence-Based Nursing Research
Context: Proper hydration is important for optimal cognitive functioning as it plays an important role in neural conductivity. Failure to consume sufficient water leads to the deterioration of cognitive and neurologic functions, and dehydration is a ...
Asmaa Othman, Sahar Mohammad, Eman Abubakr   +2 more
doaj   +1 more source

Ribavirin and Interferon Therapy for Critically Ill Patients With Middle East Respiratory Syndrome: A Multicenter Observational Study

Clinical Infectious Diseases, 2019
Background The objective of this study was to evaluate the effect of ribavirin and recombinant interferon (RBV/rIFN) therapy on the outcomes of critically ill patients with Middle East respiratory syndrome (MERS), accounting for time-varying confounders.
Y. Arabi, S. Shalhoub, Y. Mandourah, F. Al-Hameed, Awad Al-omari, E. Al Qasim, J. Jose, B. Alraddadi, Abdullah Almotairi, K. Al Khatib, A. Abdulmomen, I. Qushmaq, A. Sindi, A. Mady, O. Solaiman, Rajaa Al-Raddadi, K. Maghrabi, Ahmed Ragab, G. A. Al Mekhlafi, H. Balkhy, Abdulrahman Al Harthy, A. Kharaba, J. Gramish, Abdulsalam M Al-Aithan, A. Al-Dawood, L. Merson, F. Hayden, R. Fowler   +27 more
semanticscholar   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Early mobilization of critically ill patients in the intensive care unit: A systematic review and meta-analysis

PLoS ONE, 2019
Background Physical therapy can prevent functional impairments and improve the quality of life of patients after hospital discharge. However, the effect of early mobilization on patients with a critical illness remains unclear.
Lan Zhang, Weishu Hu, Zhiyou Cai, Jihong Liu, Jianmei Wu, Yangmin Deng, Keping Yu, Xiaohua Chen, Li Zhu, Jing-Yi Ma, Yan Qin   +10 more
semanticscholar   +1 more source

Emergency and critical care services in Tanzania: a survey of ten hospitals. [PDF]

, 2013
While there is a need for good quality care for patients with serious reversible disease in all countries in the world, Emergency and Critical Care tends to be one of the weakest parts of health systems in low-income countries.
A Iddriss, AC Cheng, AF Merry, AP Farmer, C Mock, D Konrad, D Watters, David Konrad, E Molyneux, E Molyneux, ED Riviello, Edwin Lugazia, F Abdullah, I Baelani, J Rylance, JA Crump, JA Razzak, Jaran Eriksen, JH Requejo, L Liu, L Pearson, Lars Irestedt, M Cherian, M English, M English, MW Dunser, MW Dunser, NK Adhikari, O Bataar, OC Kobusingye, P Ayieko, PS Chan, RP Dellinger, S Gove, S Jochberger, T Baker, T Nolan, Tanzania Service Provision Assessment Survey, Tim Baker, United Republic of Tanzania, Ministry of Health and Social Welfare, United Republic of Tanzania, Ministry of Health and Social Welfare, United Republic of Tanzania, Ministry of Health and Social Welfare, Victor Mwafongo, WHO, WHO, WHO, WHO, WHO, WHO, WHO, Y Amoateng-Adjepong   +50 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Probiotics in Critically Ill Patients [PDF]

Anesthesiology and Pain Medicine, 2011
The term ‘probiotic’ is derived from the Greek/Latin word “pro” and the Greek word “bios,” meaning “of life”. The concept of probiotics was first described by Metchnikoff in 1907 (1). The World Health Organization (WHO) and the Food and Agriculture Organization of the United Nations have defined probiotics as “live microorganisms, which, when ...
openaire   +2 more sources