Results 121 to 130 of about 1,764,010 (279)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

A Realist Defense of the Alien Tort Statute [PDF]

, 2011
This Article offers a new justification for modern litigation under the Alien Tort Statute (ATS), a provision from the 1789 Judiciary Act that permits victims of human rights violations anywhere in the world to sue tortfeasors in U.S. courts.
Knowles, Robert
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

From disarmament to rearmament: elements for a sociology of critique of the Pacification Police Unit Program

Vibrant: Virtual Brazilian Anthropology, 2017
Inspired by the reflections on the concept of critique proposed by Luc Boltanski and Eve Chiapello, this article presents some elements for a sociology of critique of the Pacification Police Unit (Unidade de Polícia Pacificadora - UPPs) program.
Palloma Menezes, Diogo Corrêa
doaj  

Money, income and the Lucas critique: the case for Malaysia [PDF]

, 2001
The objective of this study is to determine the usefulness of the monetary aggregates in Malaysia for policy action purposes. Money MI and M2 were tested for weak exogeneity, strong erogeneity and superexogeneity (which implies Lucas critique) within a ...
Azali, M., Baharumshah, Ahmad Zubaidi, Habibullah, Muzafar Shah   +2 more
core  

The Critique of Critique

Findings of the Association for Computational Linguistics ACL 2024
Critique, as a natural language description for assessing the quality of model-generated content, has played a vital role in the training, evaluation, and refinement of LLMs. However, a systematic method to evaluate the quality of critique is lacking.
Sun, Shichao, Li, Junlong, Yuan, Weizhe, Yuan, Ruifeng, Li, Wenjie, Liu, Pengfei   +5 more
openaire   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Congestion costing critique [PDF]

The Urban Mobility Report (UMR) is a widely-cited study that quantifies and monetises (measures in monetary units) traffic congestion costs in U.S. metropolitan regions. This report critically examines the UMR’s assumptions and methods.
Todd Litman
core