Results 81 to 90 of about 25,818 (186)

Crizotinib in patients with anaplastic lymphoma kinase-positive advanced non-small cell lung cancer versus chemotherapy as a first-line treatment

BMC Cancer, 2018
Background To compare the efficacy of crizotinib, pemetrexed and other chemotherapy regimens as a first-line treatment in patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) in real world clinical use and to ...
Jianya Zhou, Jing Zheng, Xiaochen Zhang, Jing Zhao, Yanping Zhu, Qian Shen, Yuehong Wang, Ke Sun, Zeying Zhang, Zhijie Pan, Yihong Shen, Jianying Zhou   +11 more
doaj   +1 more source

SEOM clinical guidelines for the treatment of non‑small cell lung cancer (2018) [PDF]

, 2018
Non-small cell lung cancer (NSCLC) accounts for up to 85% of all lung cancers. The last few years have seen the development of a new staging system, diagnostic procedures such as liquid biopsy, treatments like immunotherapy, as well as deeper molecular
Carcereny, Enric, García, Y., García-Campelo, Rosario, Guirado, M., Insa, A., Juan, O., Majem, Margarita, Provencio, M., Reguart, Noemi, Trigo, J. M., Universitat Autònoma de Barcelona   +10 more
core   +4 more sources

Transfer Hydrogenation: Advances in Manganese and Nickel Metal Catalysis

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Transfer hydrogenation (TH) of ketones, catalyzed by transition–metal complexes, produces alcohols, which are important building blocks in the pharmaceutical and fine chemical industries. For a long time, catalysts based on noble metals such as ruthenium, rhodium, and iridium have dominated the TH of ketones.
James Kamau, George S. Nyamato, Joanne Ogunah, Munmun Bardhan   +3 more
wiley   +1 more source

Oral Metronomic Topotecan Sensitizes Crizotinib Antitumor Activity in ALKF1174L Drug-Resistant Neuroblastoma Preclinical Models

Translational Oncology, 2017
BACKGROUND: Anaplastic lymphoma kinase (ALK) inhibitor crizotinib has proven to be effective in the treatment of ALK-mutated neuroblastoma, but crizotinib resistance was commonly observed in patients.
Libo Zhang, Bing Wu, Sylvain Baruchel
doaj   +1 more source

Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of the HER inhibitors and cytotoxic drugs [PDF]

, 2016
Increased expression and activation of human epidermal growth factor receptor (EGFR) and HER-2 have been reported in numerous cancers. The aim of this study was to determine the sensitivity of a large panel of human ovarian cancer cell lines (OCCLs) to ...
Alan M. Seddon, Albini, Aleksandra Kujawa, Appert-Collin, Arteaga, Au, Banerjee, Bapat, Bellantuono, Beltran, Bonneau, Bull Phelps, Burgos-Ojeda, Campos, Chase, Cunningham, Davidson, Davidson, Davies, Davis, Dinkelspiel, Dinkelspiel, Dutta, Elzarkaa, Engelman, Ferlay, Filip, Garcia, Gibson, Glaysher, Hanahan, Helmout Modjtahedi, Hennessy, Husseinzadeh, Ioannou, Ioannou, Ioannou, Jones, Kaye, Khelwatty, Khelwatty, Konecny, Lafky, Langdon, Lheureux, Mass, Mendelsohn, Modjtahedi, Modjtahedi, Modjtahedi, Mueller, Nimeiri, Pautier, Petrillo, Reyes, Roskoski, Roskoski, Sacks, Saito, Schilder, Secord, Serrano-Olvera, Sharadah Essapen, Sheng, Soozana Puvanenthiran, Su, Tandon, Teoh, Teplinsky, Trounson, van der Veeken, Vergote, Viloria-Petit, Walters Haygood, Weroha, Wilken, Xiao, Zhao, Zhou   +78 more
core   +1 more source

Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs

Angewandte Chemie, Volume 137, Issue 51, December 15, 2025.
A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee, Sihyeong Yi, Juhyun Bang, Hyun Choi, Seung Bum Park   +4 more
wiley   +1 more source

The National Lung Matrix Trial: translating the biology of stratification in advanced non-small-cell lung cancer [PDF]

, 2015
© The Author 2015.Background: The management of NSCLC has been transformed by stratified medicine. The National Lung Matrix Trial (NLMT) is a UK-wide study exploring the activity of rationally selected biomarker/targeted therapy combinations.
A Eyre-Walker, A Gelman, AE Locke, Allan F. McRae, AM Hancock, Andres Metspalu, Angli Xue, AR Wood, B Bulik-Sullivan, C Fuchsberger, C Sudlow, CC Chang, Chloe X. Yap, CL Hyde, Cross-Disorder Group of the Psychiatric Genomics Consortium, D Enard, D Habier, D Speed, D Speed, DG Torgerson, DM Altshuler, DR Nyholt, E Marouli, FR Day, G Davies, G Los Campos de, G Moser, GR Abecasis, Grant W. Montgomery, Greg Gibson, J Gratten, J Kelleher, J Yang, J Yang, J Yang, J Yang, JD Storey, Jian Yang, Jian Zeng, JJ Berg, JK Pritchard, JK Pritchard, JM Smith, Joseph E. Powell, Julia Sidorenko, K Walter, L Koning de, LH Uricchio, Loic Yengo, LR Lloyd-Jones, LR Lloyd-Jones, Luke R. Lloyd-Jones, M Konarzewski, Matthew R. Robinson, MC Turchin, MH Moor de, MR Robinson, N Mancuso, Naomi R. Wray, P Wass, Peter M. Visscher, PF Palamara, PM Visscher, PM Visscher, PW Messer, RD Hernandez, RL Fernando, RL Fernando, RL Fernando, Ronald de Vlaming, S Gazal, S Gravel, S McCarthy, SH Lee, SH Lee, T Johnson, TA Manolio, Tonu Esko, V Turcot, WG Hill, X Zhou, Y Field, Y Guan, Yang Wu, YB Simons   +84 more
core   +4 more sources

Crizotinib and Ceritinib Induce Apoptosis and Necrosis in Primary Rat Hepatocytes with Distinct Capacity [PDF]

, 2016
Drug development makes up a major portion of biomedical engineering research interests. The FDA oversees the introduction, experimentation, and implementation of all drugs before market approval is granted.
Salminen, Alec T
core   +1 more source

Response to erlotinib in a patient with lung adenocarcinoma harbouring the EML4-ALK translocation: A case report. [PDF]

, 2015
Lung cancer is the leading cause of cancer-associated mortality worldwide, and the mainstay of treatment remains to be personalised therapy. Tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKIs) have been reported to exert a ...
Alì, G., Boldrini, L., Chella, A., Davini, F., Fontanini, G., Lupi, C., Mussi, A., Niccoli, C., Proietti, A.   +8 more
core   +1 more source

A Case of Orbital Metastasis as Disease Progression of Anaplastic Lymphoma Kinase-Positive Lung Cancer Treated with Crizotinib

Case Reports in Oncology, 2015
Orbital metastasis of lung cancer is rare. It often causes visual disorder. To date, there are only a few case reports. Crizotinib is an anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor that leads to responses in most patients with ALK-positive
Yoshihiko Sakata, Kodai Kawamura, Kazuya Ichikado, Masakazu Yoshioka   +3 more
doaj   +1 more source