Results 131 to 140 of about 162,990 (305)

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

MOESM1 of Low toxicity and favorable clinical and quality of life impact after non-myeloablative autologous hematopoietic stem cell transplant in Crohnâ s disease

, 2017
Additional file 1. Sociodemographic and clinical characteristics.
Ruiz, Milton, Kaiser, Roberto, Quadros, Luiz, Piron-Ruiz, Lilian, PeĂąa-Arciniegas, Tatiana, Faria, Mikaell, Siqueira, Rubens, Pirozzi, Flavio, Kaiser, Fernanda, Burt, Richard   +9 more
openaire   +1 more source

Pharmacokinetic‐pharmacodynamic modelling of risankizumab using chronic plaque psoriasis real‐world data

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Risankizumab is a high‐cost biologic treatment for chronic plaque psoriasis, an immune‐mediated inflammatory disease presenting with painful red scaly skin lesions. Inter‐individual heterogeneity in treatment response may be better addressed with personalised rather than fixed dosing. We sought to develop a pharmacokinetic/pharmacodynamic (
Charlotte M. Thomas, Jessica Ruoheng Wei, David Baudry, Zehra Arkir, Bola Coker, Tejus Dasandi, Kingsley Powell, Monica Arenas‐Hernandez, Jenny Leung, Krystal Rawstron, Chioma Nwaogu, Richard Woolf, Andrew E. Pink, Jonathan Barker, Joseph F. Standing, Catherine H. Smith, Satveer K. Mahil   +16 more
wiley   +1 more source

A Rare Manifestation of Crohn's Disease: Sinonasal Granulomatosis. Report of a Case and Review of Literature

European Journal of Case Reports in Internal Medicine, 2014
Crohn’s disease is a granulomatous inflammatory bowel disease. Its pathologic findings include non-contiguous chronic inflammation and non-caseating granulomas, sometimes with extra-intestinal localizations.
Lilia Baili, Imène Rachdi, Fatma Daoud, Zohra Aydi, Basma Ben Dhaou, Samir Kochbati, Fatma Boussema   +6 more
doaj   +1 more source

MOESM3 of Low toxicity and favorable clinical and quality of life impact after non-myeloablative autologous hematopoietic stem cell transplant in Crohnâ s disease

, 2017
Additional file 3. Hematological abnormalities during autologous hematopoietic stem cell transplantation.
Ruiz, Milton, Kaiser, Roberto, Quadros, Luiz, Piron-Ruiz, Lilian, PeĂąa-Arciniegas, Tatiana, Faria, Mikaell, Siqueira, Rubens, Pirozzi, Flavio, Kaiser, Fernanda, Burt, Richard   +9 more
openaire   +1 more source

Ocrelizumab‐induced colitis: VigiBase disproportionality analysis, case reports and literature review

British Journal of Clinical Pharmacology, EarlyView.
Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse, Christophe Hommel, Nadine Petitpain, Philippe Kerschen   +3 more
wiley   +1 more source

Additional file 1: of High-intensity interval training and moderate-intensity continuous training in adults with Crohnâ s disease: a pilot randomised controlled trial

, 2019
Summary of telephone interview data. (DOCX 14 kb)
Tew, Garry, Leighton, Dean, Carpenter, Roger, Anderson, Simon, Langmead, Louise, Ramage, John, Faulkner, James, Coleman, Elizabeth, Fairhurst, Caroline, Seed, Michael, Bottoms, Lindsay   +10 more
openaire   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Additional file 3: of High-intensity interval training and moderate-intensity continuous training in adults with Crohnâ s disease: a pilot randomised controlled trial

, 2019
Implications and proposed changes for the full-scale trial. (DOCX 16 kb)
Tew, Garry, Leighton, Dean, Carpenter, Roger, Anderson, Simon, Langmead, Louise, Ramage, John, Faulkner, James, Coleman, Elizabeth, Fairhurst, Caroline, Seed, Michael, Bottoms, Lindsay   +10 more
openaire   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source