Results 121 to 130 of about 102,860 (309)

The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease. [PDF]

, 2010
Recent evidence suggests a crucial role of the endocannabinoid system, including the cannabinoid 1 receptor (CNR1), in intestinal inflammation. We therefore investigated the influence of the CNR1 1359 G/A (p.Thr453Thr; rs1049353) single nucleotide ...
Brand, Stephan, Burkhard Göke, Göke, Burkhard, Storr, Martin, Göke Burkhard, Ochsenkühn, Thomas, Stephan Brand, Brand Stephan, Thomas Ochsenkühn, Storr Martin, Pfennig, Simone, Dominik Emmerdinger, Peter Lohse, Martin Storr, Emmerdinger Dominik, Diegelmann, Julia, Lohse, Peter, Simone Pfennig, Diegelmann Julia, Emmerdinger, Dominik, Julia Diegelmann, Ochsenkühn Thomas, Lohse Peter, Pfennig Simone   +23 more
core   +1 more source

DNA (cytosine‐5)‐methyltransferase 3A (Dnmt3a) mutations limit normal and autoreactive CD4+ T follicular helper responses and attenuate T cell‐driven joint inflammation

Arthritis &Rheumatology, Accepted Article.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased inflammatory markers. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

Impact of fatigue in Crohn's disease is negatively related to resting state functional connectivity between the superior parietal lobule and parahippocampal gyrus/hippocampus

Frontiers in Human Neuroscience
IntroductionCrohn's disease is one phenotype of inflammatory bowel disease (IBD). Fatigue is a common and burdensome symptom for persons with Crohn's disease.
Theresa A. McIver, Theresa A. McIver, Theresa A. McIver, Charles N. Bernstein, Charles N. Bernstein, Ruth Ann Marrie, Ruth Ann Marrie, Chase R. Figley, Chase R. Figley, Md Nasir Uddin, Md Nasir Uddin, Md Nasir Uddin, John D. Fisk, Lesley A. Graff, Lesley A. Graff, Ronak Patel, Erin L. Mazerolle, Jennifer Kornelsen, Jennifer Kornelsen, Jennifer Kornelsen   +19 more
doaj   +1 more source

Uveitis as first manifestation of probably Crohn's disease

Revista Brasileira de Oftalmologia, 2012
Extraintestinal manifestations of Crohn's disease are common. Although ocular complications of Crohn's disease are infrequent, most ocular manifestations include iritis, uveitis, episcleritis, scleritis and conjuntivitis.
Ieda Maria Alexandre Barreira, Ricardo Evangelista Marrocos de Aragão, Ariosto Bezerra Vale, Virgínia Apolônio Vieira, Luanna Biana Costa Bezerra   +4 more
doaj   +1 more source

Additional file 1: of An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohnâ s disease

, 2015
CONSORT 2010 checklist. (DOC 217 kb)
Yoshimura, Naoki, Yokoyama, Yoko, Matsuoka, Katsuyoshi, Takahashi, Hiroki, Iwakiri, Ryuichi, Yamamoto, Takayuki, Nakagawa, Tomoo, Fukuchi, Takumi, Motoya, Satoshi, Kunisaki, Reiko, Kato, Shingo, Hirai, Fumihito, Yoh Ishiguro, Tanida, Satoshi, Hiraoka, Sakiko, Mitsuyama, Keiichi, Ishihara, Shunji, Tanaka, Shinji, Michiro Otaka, Osada, Taro, Kagaya, Takashi, Suzuki, Yasuo, Nakase, Hiroshi, Hanai, Hiroyuki, Watanabe, Kenji, Nobuhito Kashiwagi, Hibi, Toshifumi   +26 more
openaire   +1 more source

Surgical Emergencies in Crohn’s Disease [PDF]

, 2015
Crohn’s disease, as a chronic inflammatory disease of unknown etiology that can affect any part of the alimentary canal from the mouth to the anus, has a highly variable course and a very unpredictable evolution.
FALCO, Nicolo', FONTANA, Tommaso, SALAMONE, Giuseppe, Nicolò Falco, Gaspare Gulotta, Gianfranco Cocorullo, Giuseppe Salamone, TUTINO, Roberta, COCORULLO, Gianfranco, GUERCIO, Giovanni, Tommaso Fontana, GULOTTA, Gaspare, Roberta Tutino, Giovanni Guercio   +13 more
core   +1 more source

A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐07261271 in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan, Christopher Banfield, Kenneth Hung, Anna Sapone, Vivek Pradhan, Yuxi Zhao, Dana Parsons‐Rich, Grace Lee, Bryce G. Johnson, Elena Peeva, Michael S. Vincent, Valerie M. Clerin   +11 more
wiley   +1 more source

Additional file 1: of The bowel preparation for magnetic resonance enterography in patients with Crohnâ s disease: study protocol for a randomized controlled trial

, 2019
SPIRIT checklist. (DOC 117 kb)
Dai, Min, Zhang, Ting, Li, Qianqian, Cui, Bota, Xiang, Liyuan, Ding, Xiao, Rong, Rong, Bai, Jianling, Zhu, Jianguo, Zhang, Faming   +9 more
openaire   +1 more source

In situ PCR for Mycobacterium tuberculosis in endoscopic mucosal biopsy specimens of intestinal tuberculosis and Crohn disease [PDF]

, 2008
Tuberculosis and Crohn disease are granulomatous disorders affecting the intestinal tract with similar clinical manifestations and pathologic features.
Pulimood, AB, Rook, GWA, Peter, S, Donoghue, HD   +3 more
core  

Evaluating a virtual paediatric adverse drug reaction clinic

British Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck, Blanca Del Pozzo‐Magana, Michael Rieder   +2 more
wiley   +1 more source