Results 111 to 120 of about 102,860 (309)

Multimodal Integration of Protein Interactomes With Genomic and Molecular Data Discovers Distinct Rheumatoid Arthritis Endotypes

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) is a heterogeneous autoimmune disease characterized by clinical and molecular heterogeneity, notably in the presence of anti–cyclic citrullinated peptide (CCP) antibodies. Patients with CCP+ RA exhibit more severe disease progression and distinct treatment responses compared to patients with CCP− RA.
Javad Rahimikollu, Priyamvada Guha Roy, Akash Kishore, Danica Morgan Lee, Lauren A. Vanderlinden, Kiran Nazarali, Fan Zhang, Dana P. Ascherman, Daniella M. Schwartz, Larry Moreland, Jishnu Das   +10 more
wiley   +1 more source

Additional file 4: of Circulating cathelicidin levels correlate with mucosal disease activity in ulcerative colitis, risk of intestinal stricture in Crohnâ s disease, and clinical prognosis in inflammatory bowel disease

, 2017
Figure S4. Data analysis of CD clinical activity. Prevalence, sensitivity, specificity, PPV, NPV, and AUC values of ROC curves of LL-37 test alone, CRP test alone, and both in indicating (A) CD clinical remission and (B) moderate or severe CD clinical activity.
Tran, Diana, Wang, Jiani, Ha, Christina, Ho, Wendy, Mattai, S., Oikonomopoulos, Angelos, Weiss, Guy, Lacey, Precious, Cheng, Michelle, Shieh, Christine, Mussatto, Caroline, Ho, Samantha, Hommes, Daniel, Koon, Hon   +13 more
openaire   +1 more source

Fecal calprotectin reflects endoscopic activity in patients with small-bowel Crohn’s disease according to double-balloon endoscopy findings [PDF]

, 2018
2018-05Fecal calprotectin (FC) has drawn attention as a biomarker in the evaluation of Crohn’s disease (CD). However, few reports have provided a detailed examination of the relationship between small-bowel CD lesions and FC levels.
Matsuura, Rinzaburo, Matsushita, Masanobu, Ohno, Eizaburo, Miyahara, Ryoji, Watanabe, Osamu, Goto, Hidemi, Ishikawa, Takuya, Hirooka, Yoshiki, Suhara, Hiroki, Kawashima, Hiroki, Funasaka, Kohei, Nakamura, Masanao, Yamamura, Takeshi, Furukawa, Kazuhiro   +13 more
core   +1 more source

Spondyloarthritis Preceding and Following Inflammatory Bowel Disease Diagnosis and Risk Factors: A Temporal Trends Analysis in a Population‐Based Cohort

Arthritis &Rheumatology, EarlyView.
Objective Spondyloarthritides (SpA) and inflammatory bowel disease (IBD) are immune‐mediated diseases with overlap in clinical and immunologic features. However, temporal correlation of SpA and IBD in individual patients and risk factors are not well characterized.
Manasi Agrawal, Christian N. Sørensen, Gry J. Poulsen, Bahar Moghaddam, Percio S. Gulko, Jean‐Frederic Colombel, Tine Jess   +6 more
wiley   +1 more source

MOESM1 of Whole exome sequencing of patients who resolved Crohnâ s disease and complex regional pain syndrome following treatment for paratuberculosis

, 2019
Additional file 1. Variants present in selected mycobacterial susceptibility loci.
Todd Kuenstner, J., Kali, Maher, Welch, Christine   +2 more
openaire   +1 more source

A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease [PDF]

, 2011
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Barisani D., Beauchamp, C., Stokkers, P.C.F., Beauchamp, Claudine, Stokkers, Pieter C. F., David A van Heel, Annese V., Boucher, Gabrielle, van Heel, David A., Philippe Goyette, Trynka, Gosia, Palmieri, Orazio, Lagacé Caroline, David A. van Heel, Patrick C Dubois, Stokkers P. C. F., Pieter C F Stokkers, Weersma, RK, Barisani Donatella, Rioux, John D, Trynka G., Lagace, C., Festen, Eleonora A. M., Wijmenga, Cisca, Cisca Wijmenga, Daly M. J., Mark J. Daly, Caroline Lagacé, Dubois P. C., Weersma, Rinse K., Stokkers Pieter C. F., Boucher, G, Rioux John D., Palmieri O., Dubois Patrick C., Palmieri Orazio, Green Todd, Barisani, D, Hommes, Daan W, Hommes, Daan W., Vito Annese, Annese, V, Weersma R. K., van Heel, D.A., Orazio Palmieri, Annese, Vito, Trynka, G., Hommes D. W., Weersma, R.K., Goyette, P., Festen, Eleonora AM, Daly, M.J., Stokkers, PCF, Hommes, DW, Rioux, J.D., Wijmenga C., Rioux J. D., Palmieri, O., Green, T, Hommes, D.W., Daly Mark J., Beauchamp Claudine, Goyette, Philippe, Patrick C. Dubois, Barisani, D., John D Rioux, Daan W. Hommes, Lagace C., Green, Todd, Stokkers, Pieter CF, Wijmenga, C., van Heel David A., Wijmenga Cisca, Eleonora A M Festen, Weersma, Rinse K, Green T., Green, T., Wijmenga, C, Annese, V., Weersma, Rinse K.; id_orcid, Dubois, Patrick C, Dubois, PC, Hommes Daan W., Gosia Trynka, Daly, Mark J, Festen E. A. M., Lagace, C, Mark J Daly, Dubois, Patrick C., Trynka, G, Rioux, JD, Rinse K. Weersma, Goyette, P, Todd Green, van Heel, David A, Wijmenga, Cisca; id_orcid, Dubois, P.C., Lagace, Caroline, Boucher Gabrielle, Annese Vito, Donatella Barisani, Boucher, G., John D. Rioux, Beauchamp C., Weersma Rinse K., Goyette P., Rioux, John D., van Heel D. A., Palmieri, O, Gabrielle Boucher, van Heel, DA, Claudine Beauchamp, Boucher G., Daly, Mark J., Daly, MJ, Daan W Hommes, Beauchamp, C, Rinse K Weersma, Heel, D.A. van, Festen, E.A.M., Festen Eleonora A. M., Eleonora A. M. Festen, Pieter C. F. Stokkers, Festen, EAM, Barisani, Donatella, Goyette Philippe, Trynka Gosia   +126 more
core   +1 more source

Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double‐Blind, Proof‐of‐Concept Study

Arthritis &Rheumatology, EarlyView.
Objective To assess guselkumab + golimumab combination therapy versus guselkumab monotherapy in participants with active psoriatic arthritis (PsA) and inadequate response to tumor necrosis factor inhibitors (TNFi‐IR). Methods Adults with active TNFi‐IR PsA (three or more tender/swollen joints) were randomized (2:1) to subcutaneous guselkumab (100 mg) +
Jose U. Scher, Iain B. McInnes, Enrique R. Soriano, Joseph F. Merola, Paul Bird, Vinod Chandran, Edaire Cheng, Elena Reynoso, Warner Chen, Maoji Li, Lianne S. Gensler, Philip J. Mease, Christopher T. Ritchlin   +12 more
wiley   +1 more source

Non-invasive fluorescence sensing reveals changes in intestinal barrier function and gastric emptying rate in a first-in-human study of Crohn’s disease

Therapeutic Advances in Gastroenterology
Background: Crohn’s disease is characterised by multifaceted changes in gut function, involving not just inflammatory effects but also alterations in gut barrier function and gastric motility.
Jonathan Gan, Qian Chen, Elena Monfort Sanchez, Nilanjan Mandal, Jiacheng Xu, Zixin Wang, Arjun Agarwal, Emmanuel Oluwatunmise, Pratik Ramkumar, Ash Salam, Elena Chekmeneva, María Gómez-Romero, Lynn Maslen, Sharmili Balarajah, Robert Perry, Karl King Yong, Jonathan Hoare, Nick Powell, James Alexander, James Avery, Hutan Ashrafian, Ara Darzi, Alex J. Thompson   +22 more
doaj   +1 more source

Improvement with Infliximab of a Disseminated Sarcoidosis in a Patient with Crohn’s Disease

Case Reports in Pulmonology, 2014
Sarcoidosis and Crohn’s disease are systemic granulomatous disorders affecting the lung and the intestine, respectively, with variable involvement of other organs and are seldom associated.
Nader Chebib, Fabrice Piégay, Julie Traclet, François Mion, Jean-François Mornex   +4 more
doaj   +1 more source

MOESM2 of Low toxicity and favorable clinical and quality of life impact after non-myeloablative autologous hematopoietic stem cell transplant in Crohnâ s disease

, 2017
Additional file 2. Complications following autologous hematopoietic stem cell transplantation.
Ruiz, Milton, Kaiser, Roberto, Quadros, Luiz, Piron-Ruiz, Lilian, PeĂąa-Arciniegas, Tatiana, Faria, Mikaell, Siqueira, Rubens, Pirozzi, Flavio, Kaiser, Fernanda, Burt, Richard   +9 more
openaire   +1 more source