Results 171 to 180 of about 102,860 (309)

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Tiny carriers, big impact: How Fusobacterium nucleatum extracellular vesicles drive oral diseases and beyond

Interdisciplinary Medicine, EarlyView.
This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma, Jiahui Huang, Yitong Chen, Haoxuan Wang, Hang Zou, Wanghong Zhao, Zilong Deng   +6 more
wiley   +1 more source

Crohn's disease activity assessed by doppler sonography: the role of aortic flow parameters

Clinics, 2013
OBJECTIVES: Intestinal neovascularization and abnormal abdominal arterial flow rates have been reported in Crohn's disease. The aim of this study was to evaluate Doppler sonography as a method for assessing Crohn's disease activity based on changes in ...
Thais Guaraná Andrade, Homero Soares Fogaça, Celeste Carvalho Siqueira Elia, Melissa Tassano Pitrowsky, Heitor Siffert Pereira de Souza   +4 more
doaj  

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

Organ‐Specific Human Microbiomes and Dysbiosis: Mechanistic Links to Disease and Emerging Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley   +1 more source

Complicated Acute Appendicitis Conservatively Treated in Two Patients With Crohn's Disease: The Role of Intestinal Ultrasound and Contrast‐Enhanced Ultrasound

Journal of Clinical Ultrasound, EarlyView.
Intestinal ultrasound and contrast‐enhanced ultrasound were used to diagnose, monitor, and guide conservative treatment of complicated acute appendicitis in two patients with Crohn's disease. Serial imaging enabled early identification of treatment response, allowing long‐term surgery‐free outcomes.
Cataletti Giovanni, Gridavilla Daniele, Nylund Kim, Colombo Francesco, Danelli Piergiorgio, Maconi Giovanni   +5 more
wiley   +1 more source

Deep learning‐assisted design of nanozyme for immune regulation

Journal of Intelligent Medicine, EarlyView.
Overview of nanozyme‐based strategies for inflammatory bowel disease therapy, featuring metal‐based and non‐metallic nanozymes classified by structure, alongside multifunctional and engineered probiotic‐based nanozymes classified by function. Abstract Inflammatory bowel disease (IBD), with rising global incidence and disease burden, is a multifactorial
Ke Chen, Si Sun, Shaofang Zhang, Huanhuan Qiao   +3 more
wiley   +1 more source

Guidance for the assessment of the dietary intake and gastrointestinal or nutrition impact symptoms etiologic criterion of Global Leadership Initiative on Malnutrition: A modified‐Delphi study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract The GLIM malnutrition diagnostic framework includes the etiologic criterion for reduced dietary intake or assimilation (i.e., digestion or absorption). This criterion required further specification to support consistent use in clinical practice.
Renée Blaauw, Heather Keller, Christine Marie Mills, Gert Bischoff, Charlene Compher, Marian de van der Schueren, Krista Haines, Nicole Kiss, Charles Lew, Ainsley Malone, Claudia Maza Moscoso, Nancy Stoner, Rocco Barazzoni, Jack J. Bell, Madeleine Coetzee, M. Isabel T. D. Correia, Ryoji Fukushima, Elena George, M. Cristina Gonzalez, Leah Gramlich, Yen Peng Lim, Roseann Nasser, Matthias Pirlich, Jacqueline A. E. Langius, Terese Scollard, Nicolette Wierdsma, Marion Winkler, Tommy Cederholm, Gordon L. Jensen   +28 more
wiley   +1 more source