Results 101 to 110 of about 1,050,820 (318)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Research Progress and Application Advances of Controlled-Release Nitrogen Fertilizers in Crop Production

Agriculture
Against the backdrop of global population and food security challenges, improving crop nitrogen use efficiency (NUE) is essential for sustainable agriculture.
Kaiwen Zhang, Lingxiao Zhu, Hongchun Sun, Yongjiang Zhang, Ke Zhang, Zhiying Bai, Zhanbiao Wang, Liantao Liu, Cundong Li   +8 more
doaj   +1 more source

Evaluation of the Doraiswamy-Thompson winter wheat crop calendar model incorporating a modified spring restart sequence [PDF]

The Robertson phenology was used to provide growth stage information to a wheat stress indicator mode. A stress indicator model demands two acurate predictions from a crop calendar: date of spring growth initiation; and crop calendar stage at growth ...
Ravet, F. W., Smika, D., Taylor, T. W.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Spatial Patterns of Crop Yields in Latin America and the Caribbean [PDF]

Because of the apparent slowdown in the growth of crop yield potential, the increasing share of farmers already using modern crop varieties, and the accelerating flow of knowledge on agricultural technology, one would expect to find gradual convergence ...
Liangzhi You, Stanley Wood, Xiaobo Zhang
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Research activities in regional crop modelling and yield forecasting [PDF]

CGMS is being applied successfully within the MARS Crop Yield Forecasting System for qualitative monitoring of the growing season and for making quantitative crop yield forecasts.
Boogaard, H.L., Diepen, C.A., van, Wit, A.J.W., de   +2 more
core   +1 more source

Early-season growth responses of corn hybrids and inbred lines to a commercial seed treatment [PDF]

, 2020
Annual rainfall in the Midwest has increased up to 10% since the early 20th century, while approximately 20-25% of the global corn crops have experienced yearly drought.
Vagedes, Rose
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Genome-wide identification analysis in wild-type Solanum pinnatisectum reveals some genes defending against Phytophthora infestans

Frontiers in Genetics
Solanum pinnatisectum exhibits strong resistance to late blight caused by Phytophthora infestans but only an incomplete genome assembly based on short Illumina reads has been published.
Chunxiu Shen, Qineng Lu, Di Yang, Xueru Zhang, Xinping Huang, Rungen Li, Zhiqun Que, Na Chen   +7 more
doaj   +1 more source