Results 71 to 80 of about 12,344 (246)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Crop and medicinal plants proteomics in response to salt stress

Frontiers in Plant Science, 2013
Increasing of world population marks a serious need to create new crop cultivars and medicinal plants with high growth and production at any environmental situations.
Keyvan eAghaei, Setsuko eKomatsu
doaj   +1 more source

Estimating Orangutan Densities Using the Standing Crop and Marked Nest Count Methods: Lessons Learned for Conservation

Biotropica, 2010
ABSTRACTReliable estimates of great ape abundance are needed to assess distribution, monitor population status, evaluate conservation tactics, and identify priority populations for conservation. Rather than using direct counts, surveyors often count ape nests.
Spehar, S N, Mathewson, P D, Nuzuar, Mr, Wich, S A, Marshall, A J, Kühl, H, Nardiyono, Mr, Meijaard, E   +7 more
openaire   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

GIS spatial optimization for agricultural crop allocation using NSGA-II

Information Processing in Agriculture
This study focuses on the shift from traditional farming methods, reliant on farmer intuition and manual processes, to modern, automated approaches crucial for Thailand’s agricultural sustainability.
Tipaluck Krityakierne, Pornpimon Sinpayak, Noppadon Khiripet   +2 more
doaj   +1 more source

Regional and global shifts in crop diversity through the Anthropocene.

PLoS ONE, 2019
The Anthropocene epoch is partly defined by anthropogenic spread of crops beyond their centres of origin. At global scales, evidence indicates that species-level taxonomic diversity of crops being cultivated on large-scale agricultural lands has ...
Adam R Martin, Marc W Cadotte, Marney E Isaac, Rubén Milla, Denis Vile, Cyrille Violle   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Sergey Fedorovich Gavrish a head of Research Institute of Protected Vegetable Cultivation celebrates his 60^th birthday

Овощи России, 2010
On 1 November a leading scientists of Russia in vegetable plant breeding and seed production, a head of Research Institute of Protected Vegetable Cultivation, professor, principal scientist in plant breeding Sergey Fedorovich Gavrish marks his 60th ...
E.G. Dobrutskaya, L.K. Gurkina
doaj  

Regionalising a global gridded crop model using satellite-based phenology for water footprint analysis in the Upper Syr Darya Basin

Journal of Hydrology: Regional Studies
Study region: The Upper Syr Darya Basin (USB) in Central Asia is a transboundary, water-stressed system where cotton production depends on irrigation, and ground-based monitoring is sparse.
Gautamee Baviskar, Timothy Foster, Rick J. Hogeboom, Han Su, Oleksandr Mialyk, Maarten S. Krol   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source