Results 81 to 90 of about 12,344 (246)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Artificial intelligence and its applications in agriculture: A review

Environment Conservation Journal
The application of artificial intelligence (AI) into agriculture marks a huge shift in the sector, providing solutions for increasing crop yields, pest control, and overall food supply chain management.
Peddi Naga Harsha Vardhan, Akhila Badavath, Pulla Srivalli   +2 more
doaj   +1 more source

Spectral sensitivity of ALOS, ASTER, IKONOS, LANDSAT and SPOT satellite imagery intended for the detection of archaeological crop marks

International Journal of Digital Earth, 2012
This study compares the spectral sensitivity of remotely sensed satellite images, used for the detection of archaeological remains.
Athos Agapiou, Dimitrios D. Alexakis, Diofantos G. Hadjimitsis   +2 more
openaire   +4 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Genome-wide identification of histone methylation (H3K9me2) and acetylation (H4K12ac) marks in two ecotypes of switchgrass (Panicum virgatum L.)

BMC Genomics, 2019
Background Histone modifications play a significant role in the regulation of transcription and various biological processes, such as development and regeneration.
Vasudevan Ayyappan, Venkateswara R. Sripathi, Venu ( Kal) Kalavacharla, Malay C. Saha, Jyothi Thimmapuram, Ketaki P. Bhide, Elizabeth Fiedler   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Design and development of agricultural drone for precision fertilizer application to optimize crop yields

Results in Engineering
In the modern era, precision agriculture has advanced significantly, playing a crucial role in improving crop yields - especially in countries such as India, where more than 70% of the rural population depends on agriculture.
Amartya Josephat, Aravindkumar Sekar, Deepa T, S. Angalaeswari   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Aerial Remote Sensing Archaeology—A Short Review and Applications

Land
Aerial and remote sensing archaeology are tools for identifying marks on images of archaeological remains covered by soil. In other words, they are archaeological prospection tools that fall into the category of non-destructive research methods.
Dimitris Kaimaris
doaj   +1 more source

Soil health and dragon fruit cultivation: Assessing the impact on soil organic carbon

Scientia Agropecuaria, 2023
Soil organic carbon (SOC) plays a crucial role in soil quality and nutrient availability. Agricultural practices, such as tillage and crop rotations, can affect SOC levels.
Saskia Guillen, Geoconda López, Paola Ormaza, Freddy Mesias, Ewa Błońska , Lizardo Reyna-Bowen   +5 more
doaj