Results 121 to 130 of about 7,744,808 (358)

Evidence of crop production losses in West Africa due to historical global warming in two crop models

Scientific Reports, 2019
Achieving food security goals in West Africa will depend on the capacity of the agricultural sector to feed the rapidly growing population and to moderate the adverse impacts of climate change.
B. Sultan, D. Defrance, T. Iizumi
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Generating Global Crop Distribution Maps: From Census to Grid [PDF]

In order to evaluate food security, technology potential and the environmental impacts of production in a strategic and regional context, it is critical to have reliable information on the spatial distribution and coincidence of people, agricultural ...
Wood, Stanley, Wood-Sichra, Ulrike, You, Liangzhi   +2 more
core   +4 more sources

Onion (Allium cepa L.) and Drought: Current Situation and Perspectives

Scientifica
Onions (Allium cepa L.) are the second most commonly produced and consumed vegetable worldwide due to their economic, nutritional, and medicinal benefits.
Oladé Charles Sansan, Vincent Ezin, Mathieu Anatole Tele Ayenan, Ifagbémi Bienvenue Chabi, Hubert Adoukonou-Sagbadja, Aliou Saïdou, Adam Ahanchede   +6 more
doaj   +1 more source

STRATEGIES TO INCREASE AGRICULTURAL PRODUCTIVITY AND REDUCE LAND DEGRADATION: EVIDENCE FROM UGANDA [PDF]

This paper estimates a structural econometric model of household decisions regarding income strategies, participation in programs and organizations, crop choices, land management, and labor use, and their implications for agricultural production and land
Jagger, Pamela, Nkonya, Ephraim M., Pender, John L., Ssali, Henry, Sserunkuuma, Dick   +4 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Application of slow-controlled release fertilizer coordinates the carbon flow in carbon-nitrogen metabolism to effect rice quality

BMC Plant Biology
Slow-controlled release fertilizers are experiencing a popularity in rice cultivation due to their effectiveness in yield and quality with low environmental costs.
Zhengrong Jiang, Qiuli Chen, Dun Liu, Weike Tao, Shen Gao, Jiaqi Li, Chunhao Lin, Meichen Zhu, Yanfeng Ding, Weiwei Li, Ganghua Li, Soulaiman Sakr, Lihong Xue   +12 more
doaj   +1 more source

Estimating the potential of rain-fed agriculture [PDF]

Irrigation management / Water management / Irrigated farming / Rain-fed farming / Crop production / Food production / Irrigation effects / Climate / Models / Soil-water-plant relationships / Crop yield ...
Droogers, P., Makin, I., Seckler, D.
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source