Results 31 to 40 of about 3,064,644 (258)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Biorational Reflections in Agricultural Chemical Research

CHIMIA, 1984
The future of agricultural chemical research will be determined by three major factors: a) by the diminishing success rate of conventional synthesis and biological screening procedures; b) by the accentuating demand on agriculture to adapt its ...
Hans Geissbühler
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Constraints of Adoption of Agricultural Extension Package Technologies on Sorghum Crop Production at Smallholder Farm Household Level: Evidence from West Hararghe Zone, Oromia, Ethiopia

Advances in Agriculture, 2021
An effective and efficient agricultural extension system can enhance the agricultural productivity and production of smallholders through the development of innovative, systematic, and farmer-owned agricultural extensions.
Muhammed Shako, Adunea Dinku, Waktola Mosisa   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Crystal engineering in the development of improved pesticide products

Advanced Agrochem, 2022
Pesticides might be the only group of poisonous chemicals that are widely sprayed into the environment, but the use of pesticides is inevitable for crop protection and infectious disease control.
Xiaofang Niu, Rui Yang, Huimin Zhang, Jingxiang Yang   +3 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impacts of Climate Change on indirect human exposure to pathogens and chemicals from agriculture [PDF]

, 2008
Objective: Climate change is likely to affect the nature of pathogens and chemicals in the environment and their fate and transport. Future risks of pathogens and chemicals could therefore be very different from those of today.
Hardy, Anthony, Levy, Leonard, Richard J. Williams, Boucard, Tatiana, Falloon, Peter D, Peter D. Falloon, Turley, David B, Levy, Leonard S., Gordon Nichols, Wellington, Elizabeth M H, Stone, D, Stone, David, Williams, Richard J., Tatiana Boucard, Boxall, AB, Williams, Richard, Boucard, T, Buelke, Sabine, Parsons, Simon, Boxall, Alistair BA, Wellington, Elizabeth MH, Leonardi, Giovanni, Leonardi, G, Kerry Walsh, Edward Topp, Walsh, Kerry, Boxall, Alistair B. A., Thomas Hutchinson, Parsons, Simon A, Kovats, RS, David Stone, Burgin, Laura, Haygarth, Philip, Wellington, Elizabeth, Parsons, SA, Kovats, R Sari, David B. Turley, Nichols, G, Nichols, Gordon, Falloon, Peter, Haygarth, Philip M, Topp, E, Levy, Leonard S, Haygarth, PM, Anthony Hardy, Hutchinson, T, Leonard S. Levy, Alistair B.A. Boxall, Laura Burgin, Kovats, R. Sari, Giovanni Leonardi, Haygarth, Philip M., Turley, David B., Parsons, Simon A., Beulke, Sabine, Williams, RJ, Wellington, EMH, Elizabeth M.H. Wellington, Beulke, S, Hutchinson, Thomas, Turley, DB, Levy, LS, Potts, L, Falloon, PD, Philip M. Haygarth, Simon A. Parsons, Sabine Beulke, R. Sari Kovats, Boxall, ABA, Boxall, Alistair, Hardy, A, Falloon, Peter D., Wellington, Elizabeth M. H., Potts, Laura, Topp, Edward, Walsh, K, Boxall, Alistair B.A., Boxall, Alistair B A, Kovats, Sari, Turley, David, Burgin, L, Wellington, E. M. H., Laura Potts, Williams, Richard J, Hutchinson, TH   +84 more
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source