Results 41 to 50 of about 3,064,644 (258)

The biological activities of Citrus species in crop protection

Journal of Agriculture and Food Research
Citrus, a globally cultivated genus, is rich in bioactive compounds like flavonoids and essential oils, known for their health benefits and antimicrobial properties.
Marta Lo Vetere, Valeria Iobbi, Anna Paola Lanteri, Andrea Minuto, Giovanni Minuto, Nunziatina De Tommasi, Angela Bisio   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

TAC Panel on Crop Protection Research: Report

, 1990
Report of the TAC Panel on Crop Protection Research, part of the process of considering ICIPE for support by the CGIAR. It was one of seven such panels created as part of the TAC assessment of non associated centers for support from the CGIAR.
CGIAR Technical Advisory Committee Panel on Crop Protection Research
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Root-knot Nematode Penetration and Sclareol Nematicidal Activity Assays

Bio-Protocol, 2016
Plant parasitic nematodes parasitize roots and/or stems of various plants thereby inhibiting absorption of nutrients and moisture. In particular, root-knot nematodes (RKN) are a group of the most devastating pests.
Taketo Fujimoto, Takayuki Mizukubo, Hiroshi Abe, Shigemi Seo   +3 more
doaj   +1 more source

Exploiting phytochemicals for developing a 'push-pull' crop protection strategy for cereal farmers in Africa

, 2010
Lepidopteran stemborers and parasitic weeds in the genus Striga are major constraints to efficient production of cereals, the most important staple food crops in Africa.
A. M. Hooper, Pickett, J. A., Z. R. Khan, Bruce, T. J. A., Hooper, A. M., Pickett, John A., Midega, Charles A. O., J. A. Pickett, T. J. A. Bruce, Khan, Z. R., C. A. O. Midega, Midega, C. A. O., Hooper, Antony M., Bruce, Toby J. A., Khan, Zeyaur R   +14 more
core   +1 more source

GM as a route for delivery of sustainable crop protection [PDF]

, 2011
Modern agriculture, with its vast monocultures of lush fertilized crops, provides an ideal environment for adapted pests, weeds, and diseases. This vulnerability has implications for food security: when new pesticide-resistant pest biotypes evolve they ...
T. J. A. Bruce, Bruce, T. J. A.
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Negative Effects of Chemicals Used Against Potato Pathogens on the Natural Environment

Вісник Харківського національного університету імені В.Н. Каразіна: Серія Екологія, 2019
Purpose. This study focused on the analysis of chemicals most often used against potato pathogens and their negative impact on both water and soil ecosystems, as well as the search for alternative solutions. This aspect is extremely important since the
A. Bekhter, K. Śmigielski
doaj   +1 more source