Results 91 to 100 of about 27,133 (307)

Evaluation of surface water drainage systems for cropping in the Central Highlands of Ethiopia

open access: yes, 2009
Published ArticleIn Ethiopia vertisols cover about 10% of the total land area and is the fourth most important soil used for crop production, accounting for nearly 23% of the total arable land used for crop production. More than half of the vertisols are
WOYESSA, Y.E., Welderufael, W.A.
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Trend of Crop Water Requirement at Akola (Maharashtra), India

open access: yes, 2017
Climate change scenario badly affects the agriculture. The present study aimed to characterize the trend in maximum temperature and crop water requirement over a last decade at Akola station (Maharashtra State), because of changing trend in ...
Lokhande, J. N.   +5 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Rainfall analysis in relation to rice crop for Jaintia Hills district of Meghalaya

open access: yesJournal of Agrometeorology, 2008
The long term rainfall data for Sali rice season (June-November) of Jaintia Hills district, Meghalaya has been analyzed to estimate expected weekly rainfall at various probability levels.
B. GOSWAMI   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Breeding for improved nitrogen use efficiency in oilseed rape [PDF]

open access: yes, 2008
Oilseed rape has a high requirement for nitrogen (N) fertiliser relative to its seed yield. This paper uses published and unpublished work to explore the extent to which the N use efficiency (seed yield ÷ N supply) of oilseed rape could be improved ...
Spink, J. H. (John H.)   +4 more
core  

FAO Reference evapotranspiration and crop water requirement of apple (Malus Pumila) in Kashmir Valley

open access: yes, 2017
Reference evapotranspiration is a significant agrometeorological parameter used for estimation of crop water requirement and irrigation scheduling. The present study was undertaken to determine the reference evapotranspiration and crop water requirement ...
SAQIB PARVAZE   +3 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

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