Results 201 to 210 of about 260,191 (318)

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

The magic of crop wild relatives in durum wheat breeding [PDF]

, 2019
Al Abdallat, Ayed, Alahamad, Samir, Alary, Véronique, Amri, Ahmed, Azouz, Mounira, Bassi, Filippo M., Baum, Michaël, Belkadi, Bouchra, El Hassouni, Khaoula, Filali-Maltouf, Abdelkarim, Hickey, Lee, Kabbaj, Hafssa, Kehel, Zakaria, Niane, Abdul Aziz, Ortiz, Rodomiro, Sall, Amadou Tidiane, Zaim, Meryem   +16 more
core  

International exchange of genetic resources, the role of information and implications for ownership: the case of the U.S. National Plant Germplasm System [PDF]

"Changing perceptions of resource ownership have altered international exchange of genetic resources. After summarizing the role of genebanks and issues related to property regimes, this paper presents an empirical study of one of the largest national ...
Rubenstein, Kelly Day, Smale, Melinda
core  

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

Genomic resources for crop wild relatives are critical for perennial fruit breeding and conservation. [PDF]

Am J Bot
Migicovsky Z.
europepmc   +1 more source

TRANSGENIC CROPS AND THE ENVIRONMENT: MISSING MARKETS AND PUBLIC ROLE [PDF]

The rapidity of change has left scant opportunity for investigation of the consequences of biotechnology adoption on long-term ecosystem or economic system functioning.
Batie, Sandra S., Ervin, David E.
core   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Identification of hotspots of crop wild relatives in Germany to promote their in situ conservation in a network of genetic reserves. [PDF]

Bot Stud
Bönisch M, Senße V, Engst T, Sander A, Matthies D, Jedicke E, Bernhardt N.   +6 more
europepmc   +1 more source

Crop genetic resources manage risks in China. How to manage risks to crop genetic resources? [PDF]

, 2020
Liu, X., Zhang, Z.
core  

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source