Results 131 to 140 of about 870,191 (308)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

MODELING MULTIVARIATE CROP YIELD DENSITIES WITH FREQUENT EXTREME EVENTS [PDF]

Measuring the lower tail of a crop yield distribution is important for managing agricultural production risk and rating crop insurance. Common parametric techniques encounter difficulties when attempting to model extreme yield events.
Chen, Shu-Ling, Miranda, Mario J.
core   +1 more source

Dinitrogen fixation and residue nitrogen of different managed legumes and nitrogen uptake of subsequent winter wheat [N2-Fixierung und residualer Stickstoff verschiedener Futterleguminosen sowie N-Aufnahme der Folgefrucht Winterweizen.] [PDF]

, 1999
Fixed nitrogen accumulated by legumes is the main nitrogen source for organic farming systems. Knowledge about the amount of fixed nitrogen, its pathways into forage yield, crop residues, soil-N and yield formation of the following crop is needed for ...
Kaske, A., Loges, Ralf, Taube, F.
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Correlation maps to assess soybean yield from EVI data in Paraná State, Brazil

Scientia Agricola
Vegetation indices are widely used to monitor crop development and generally used as input data in models to forecast yield. The first step of this study consisted of using monthly Maximum Value Composites to create correlation maps using Enhanced ...
Gleyce Kelly Dantas Araújo Figueiredo, Nathaniel Allan Brunsell, Breno Hiroyuki Higa, Jansle Vieira Rocha, Rubens Augusto Camargo Lamparelli   +4 more
doaj   +1 more source

Genetic control of plasticity of oil yield for combined abiotic stresses using a joint approach of crop modeling and genome-wide association

, 2017
Understanding the genetic basis of phenotypic plasticity is crucial for predicting and managing climate change effects on wild plants and crops.
André, Thierry, Blanchet, Nicolas, Boniface, Marie-Claude, Cadic, Eléna, Carrère, Sébastien, Casadebaig, Pierre, Coque, Marie, Gouzy, Jérôme, Langlade, Nicolas B., Laporte, Marion, Legrand, Ludovic, Mangin, Brigitte, Mayjonade, Baptiste, Muños, Stéphane, Piquemal, Joël, Pouilly, Nicolas, Vincourt, Patrick   +16 more
core   +4 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Sustainable Crop Yield Prediction

International Research Journal on Advanced Engineering Hub (IRJAEH)
Accurate forecasting of crop yields is fundamental to improving agricultural efficiency and ensuring global food availability. This research implements machine learning methodologies to estimate crop output using key agronomic and environmental indicators, such as precipitation, pesticide application, mean temperature, and carbon emissions.
null Aman Pramod Kumbhar, null Ashutosh Kulkarni, null Shaili Kakde, null Shreya Gupt, null Vaishali Jadhav   +4 more
openaire   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source