Results 111 to 120 of about 2,692,904 (342)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The efficiency of a durum wheat-winter pea intercrop to improve yield and wheat grain protein concentration depends on N availability during early growth [PDF]

, 2010
Grain protein concentration of durum wheat is often too low, particularly in low-N-input systems. The aim of our study was to test whether a durum wheat - winter pea intercrop can improve relative yield and durum wheat grain protein concentration in low ...
Bedoussac, Laurent, Justes, Eric
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Assessing populations of the major cereal pathogens for reduced sensitivity to MBC, DMI and Strobilurin fungicides [PDF]

, 2009
End of project reportStudies of eyespot populations in winter wheat crops in the period 2001 to 2003 showed that the R type (Tapesia acuformis) is the dominant strain comprising 77% of isolates. Over 90% of isolates were resistant to MBC fungicides, 53%
O'Sullivan, Eugene
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Use of Chlorophyll Meters to Assess Crop N Status and Derivation of Sufficiency Values for Sweet Pepper [PDF]

, 2019
Chlorophyll meters are promising tools for improving the nitrogen (N) management of vegetable crops. To facilitate on-farm use of these meters, sufficiency values that identify deficient and sufficient crop N status are required.
De Souza Ibarra, Stefani Romina, Gallardo Pino, María Luisa, Grasso, Rafael, Padilla Ruiz, Francisco Manuel, Peña Fleitas, María Teresa, Thompson, Rodney   +5 more
core   +1 more source

SCIENTIFIC BASIS OF CROP CROPPING.

, 2022
The purpose of the research: The scientific basis of alternating sowing of crops by fields and years is called crop rotation. Such alternating planting creates conditions for controlling the amount of organic matter in the soil, effective control of weeds, plant diseases and pests, provides the granular structure of the soil, improves the nutrition and
openaire   +1 more source

Polyphenol Oxidases in Crops: Biochemical, Physiological and Genetic Aspects

International Journal of Molecular Sciences, 2017
Enzymatic browning is a colour reaction occurring in plants, including cereals, fruit and horticultural crops, due to oxidation during postharvest processing and storage. This has a negative impact on the colour, flavour, nutritional properties and shelf
F. Taranto, A. Pasqualone, G. Mangini, P. Tripodi, M. Miazzi, Stefano Pavan, C. Montemurro   +6 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Fertilization of Agronomic Crops

EDIS, 2017
Development of fertilization programs for Florida field or forage crops requires that consideration be given to nutrient requirements for each crop, soil nutrient levels, reactions of the soil with added nutrients, and the ability of the soil to retain ...
C. Mackowiak, D.L. Wright
doaj   +1 more source