Results 91 to 100 of about 811,494 (257)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Is there any future for cash crops in developing countries? The case of vanilla. [PDF]
A generally used term for easy marketable commodities usually with high prices is cash crops As a result of it these commodities are produced by many developing and especially least developed countries (LDC).
Smutka, Lubos, Pokorna, Irena
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Residual effects of preceding crops on wheat yield and profitability [PDF]
, 2020 Non-Peer ReviewedA four-year cycle crop rotation study (cereal crop with a range of legumes and oilseeds at different frequencies and sequences in rotation) was established from 2010-2018 at three locations in western Canada to evaluate the effects of ...
Gan, Yantai +3 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Genetically Modified Crops and Labor Savings in US Crop Production [PDF]
In spite of widespread adoption there is mixed evidence as to whether or not adopting Genetically Modified (GM) crops increase farm welfare. One possible reason for widespread adoption is labor savings.
Nelson, Carl H., Gardner, Justin G.
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The regulatory landscape of genetically engineered crops in Pakistan
Food and Energy SecurityGenome editing technology has become part and parcel of biotechnological approach to understand the genetic basis of different biological processes in an organism and for its application in different fields.
Muhammad Awais +10 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Demographic and Management Factors Affecting the Adoption and Perceived Yield Benefit of Winter Cover Crops in the Southeast [PDF]
The inclusion of cover crops in cropping systems brings direct and indirect costs and benefits. Farmers will adopt and utilize cover crops as long as the perceived benefit of using them is positive.
Duffy, Patricia A. +3 more
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source