Results 81 to 90 of about 1,651,802 (314)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Advances in the Application of Nanocomposite Hydrogels in Crops
GelsConventional agricultural practices, based on intensive irrigation and heavy fertilizer and pesticide inputs, are increasingly incompatible with climate change, soil degradation, and sustainability goals.
Diego Gael Hernández-Echave +7 more
doaj +1 more source
Ethics and Genetically Modified Foods [PDF]
, 2001 Gary Comstock considers whether it is ethically justified to pursue genetically modified (GM) crops and foods. He first considers intrinsic objections to GM crops that allege that the process of making GMOs is objectionable in itself.
Comstock, Gary
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Frontiers in Plant ScienceRoot exudates are crucial for driving belowground ecosystem dynamics and subterranean chemical interactions. Cyperus rotundus (purple nutsedge) is a highly invasive weed, notoriously resistant to conventional control and causing significant crop losses ...
Giulia Giorgi +15 more
doaj +1 more source
Seeds of Doubt: North American farmers' experiences of GM crops [PDF]
, 2002 The picture the biotechnology industry has painted of GM crops in North America is one of unqualified success, after six years of commercial growing. The objective of this report was to assess whether this image is accurate and if not what problems have ...
Meziani, Gundula, Warwick, Hugh
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Native bees (Hymenoptera: Apoidea) and berry polycultures: Studying farmers’ motivations for diversification and the impact of mass floral resources on pollinator communities [PDF]
, 2017 Floral resource continuity is an important component in pollinator conservation. Mass blooms early in the season may bolster pollinator communities on sequentially flowering crops by creating a resource pulse in an agricultural landscape.
Hayes, Jen
core +1 more source
Contributions of biotechnology to meeting future food and environmental security needs [PDF]
, 2018 Biotechnology, including genetic modifications, can play a vital role in helping to meet future food and environmental security needs for our growing population.
Gartland, Jill S., Gartland, Kevan
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source