Results 111 to 120 of about 1,651,802 (314)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Plant-parasitic nematode disease complexes as overlooked challenges to crop production
Frontiers in Plant SciencePlant diseases are caused by various microorganisms such as bacteria, fungi, viruses, and nematodes. These diseases impact crop growth, reduce produce quality, and lead to financial losses.
Luisa M. Parrado, Marisol Quintanilla
doaj +1 more source
Forage Brassica Variety Trial [PDF]
, 2015 Forage brassicas can provide a near-concentrate type diet late in the grazing season. This allows for an extra grazing opportunity after summer annuals are harvested or to supplement perennial cool season pasture during the fall months.
Calderwood, Lily +6 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Is organic farming a mitigation option? – A study on N2O emission from winter wheat [PDF]
, 2009 The objective of the study was to evaluate whether N2O emissions from cropping systems are affected by 1) organic versus conventional farming, 2) proportion of N2-fixing crops in the rotation and 3) use of catch ...
Albert, Kristian R. +2 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Nitrate leaching from arable crop rotations in organic farming [PDF]
, 2003 The crop rotation is a crucial and integral part of organic farming systems. It must be designed to maintain and exploit soil fertility, and to minimise the impacts on environment, e.g. through nitrate leaching.
Askegaard, Margrethe, Olesen, Jørgen E.
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