Results 31 to 40 of about 4,735,354 (239)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Occurrence and diversity of Gram-negative bacilli in restrooms of a higher education institution in Pernambuco, Brazil

Cadernos Cajuína
Public restrooms are environments prone to cross-contamination by Gram-negative bacilli (GNB), but data on their diversity and resistance profile in higher education institutions in Northeast Brazil remain scarce.
Jorge Belém Oliveira Júnior, Lara Belfort Lustosa Martins, Antônio Carlos Freitas Souza, Ana Beatriz Sotero Siqueira   +3 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Semi-quantitative risk assessment on Listeria monocytogenes in retail Chinese salads for Shanghai residents

Zhongguo shipin weisheng zazhi, 2020
Objective To elucidate the prevalence of Listeria monocytogenes in Chinese salads in Shanghai, and to explore measures that can avoid cross-contamination and reduce the risk of infection caused by L. monocytogenes in salads.
Xia SONG, Hua CAI, Biyao XU, Baozhang LUO, Jingjin YANG, Hong LIU   +5 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Knowledge and Awareness of Food Safety, Foodborne Diseases, and Microbial Hazards Among Consumers of Street‐Vended Foods in Kandahar City, Afghanistan: A Cross‐Sectional Study

Health Science Reports
Background Common foods found in the streets of Kandahar City include flatbreads (naan), fried stuffed flatbreads (bolani), fried meat (kebabs), rice dishes, fried snacks, seasonal fruit juices, and milk and tea sold from carts, small stalls, or open‐air
Ahmadullah Zahir, Sayeed Hikmatullah Anis, Safiullah Jauhar   +2 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Use of Clinical UV Chamber to Disinfect Dental Impressions: A Comparative Study [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: Dental impressions are potential source of infection in a prosthodontic practice. Risk of transmission of infection through saliva, blood etc is considered as hazard for both dentist as well as dental auxiliary staff. A number of methods
Himanshu Aeran, Sakshi Sharma, Varun Kumar, Neelu Gupta   +3 more
doaj   +1 more source

Cross-contamination Risk Assessment using FMEA tool [PDF]

In pharmaceutical manufacturing facilities, products with different therapeutic properties and potencies are manufactured in shared spaces, which poses a potential risk for cross-contamination.
Pathodiya, Manish
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source