Results 1 to 10 of about 68,296 (153)
Ionophore Toxicity in Animals: A Review of Clinical and Molecular Aspects
International Journal of Molecular Sciences, 2023 For many years, ionophores have been used to control coccidiosis in poultry. However, misuse of ionophores can cause toxicity with significant clinical symptoms. The most critical factors influencing ionophores’ toxicity are administration dose, species,
Małgorzata Olejnik +2 more
exaly +2 more sources
Restoration of Motility in Acrosome-Reacted Boar Spermatozoa Induced by the Ionophore 4-Br-A23187. [PDF]
Reprod Domest AnimABSTRACT The acrosome reaction (AR) is a calcium‐dependent exocytotic event required for successful fertilization. Calcium ionophores are commonly used to induce AR in vitro; however, this treatment is associated with a significant loss of sperm motility. The aim of this study was to evaluate the recovery of motility in boar spermatozoa after ionophore‐
Martín-Hidalgo D +3 more
europepmc +2 more sources
Anti-Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap-Mediated Bone Loss in Rheumatoid Arthritis. [PDF]
Arthritis RheumatolObjective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Nakabo S +9 more
europepmc +2 more sources
Copaiba oleoresin as a substitute for sodium lasalocid in high-concentrate diets for lambs: growth performance, ingestive behavior, and metabolic and ruminal parameters. [PDF]
J Sci Food AgricAbstract BACKGROUND The indiscriminate and excessive use of ionophore additives has been associated with the emergence of multi‐resistant pathogenic strains and the global spread of antibiotic resistance, raising serious public health concerns. Thus, plant biocompounds have been the focus of several studies aiming to replace ionophore additives in ...
de Pantoja JC +8 more
europepmc +2 more sources
Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy
Journal of experimental & clinical cancer research : CR, 2022 Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past, elesclomol was recognized as an inducer of oxidative stress, but now it has also been found to suppress cancer by inducing cuproptosis.
Pei-Jie Zheng +4 more
semanticscholar +1 more source
Frontiers in Physiology, 2022 This study aimed to evaluate the efficacy and safety of calcium ionophore during assisted oocyte activation (AOA). This meta-analysis contained randomized controlled trials and prospective observational and retrospective trials.
Yinghua Shan +5 more
semanticscholar +1 more source
Frontiers in Endocrinology, 2021 Calcium is a crucial factor in regulating the biological behavior of cells. The imbalance of calcium homeostasis in cytoplasm will cause abnormal behavior of cells and the occurrence of diseases.
Ziwen Xu +8 more
semanticscholar +1 more source
In Analysis, 2020 The monitoring of ammonium ion concentration has gained the attention of researchers from multiple fields since it is a crucial parameter with respect to environmental and biomedical applications.
M. Cuartero +3 more
semanticscholar +1 more source
Nature Communications, 2020 The selective transport of ions across cell membranes, controlled by membrane proteins, is critical for a living organism. DNA-based systems have emerged as promising artificial ion transporters.
M. Debnath +5 more
semanticscholar +1 more source