Results 31 to 40 of about 32,536 (208)

Ionophore antibiotics and hop cones as regulators of digestion and metabolism in ruminants

open access: yesБіологічні студії
The general characteristics of ionophore antibiotics and the mechanisms of their antimicrobial action were analyzed. Two types of ionophore antibiotics are known: those that transport ions across the membrane, and those that form a channel in the cell ...
Ihor Vudmaska   +2 more
doaj   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

open access: yesAdvanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung   +19 more
wiley   +1 more source

Parâmetros ruminal, sangüíneo e urinário e digestibilidade de nutrientes em novilhas leiteiras recebendo diferentes níveis de monensina Effects of different dietary levels of monensin on nutrient digestibility and on ruminal, blood and urinary metabolites in dairy heifers

open access: yesRevista Brasileira de Zootecnia, 2005
Objetivou-se verificar a influência da inclusão de diferentes níveis do ionóforo monensina sódica na dieta sobre os parâmetros ruminal, sangüíneo e urinário e a digestibilidade aparente em novilhas leiteiras.
Marcus Vinicius Morais de Oliveira   +6 more
doaj   +1 more source

Effect of an Alliaceae Encapsulated Extract on Growth Performance, Gut Health, and Intestinal Microbiota in Broiler Chickens Challenged with Eimeria spp.

open access: yesAnimals, 2023
This study analyzed the effects of an Alliaceae encapsulated extract (AE-e) on daily gain (ADG), feed intake (ADFI), feed conversion ratio (FCR), oocysts per gram of feces (OPG), intestinal lesion (LS), and microbiota composition in broilers challenged ...
Gonzalo Villar-Patiño   +7 more
doaj   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

open access: yesAdvanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr   +19 more
wiley   +1 more source

Next-Generation Potentiometric Sensors: A Review of Flexible and Wearable Technologies

open access: yesBiosensors
In recent years, the field of wearable sensors has undergone significant evolution, emerging as a pivotal topic of research due to the capacity of such sensors to gather physiological data during various human activities. Transitioning from basic fitness
Mahmoud Abdelwahab Fathy   +1 more
doaj   +1 more source

PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy

open access: yesAdvanced Science, EarlyView.
Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen   +17 more
wiley   +1 more source

Impact of Monensin Sodium and Essential Limonene Oil on the Fermentation and Chemical Composition of Total Mixed Ration Silages with Moisture Variations

open access: yesAgriculture
Monensin and essential oils have antimicrobial properties that may impact silage fermentation. The present study was divided into two trials to evaluate the effects of monensin (MON) and essential limonene oils (ELO) as additives in the ensiling of total
Ronnie Coêlho de Andrade   +7 more
doaj   +1 more source

Chloroquine Is a Zinc Ionophore

open access: yesPLoS ONE, 2014
Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis.
Jing Xue   +5 more
openaire   +4 more sources

NIR‐II Light‐Triggered Electron Flow Initiates Cuproptosis‐Centered Thermoelectric‐Immunotherapy for Breast Cancer

open access: yesAdvanced Science, EarlyView.
A NIR‐II light‐activatable thermoelectric nanoreactor converts surface‐bound Cu2+ into bioactive Cu+ via directed electron flow. This spatiotemporally controlled reduction triggers potent cuproptosis and immunogenic cell death, eradicating primary tumors and, together with aPD‐1 therapy, suppressing metastases while establishing durable immune memory ...
Boyu Yuan   +10 more
wiley   +1 more source

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