Assisted Oocyte Activation With Calcium Ionophore Improves Pregnancy Outcomes and Offspring Safety in Infertile Patients: A Systematic Review and Meta-Analysis [PDF]
Frontiers in Physiology, 2022 This study aimed to evaluate the efficacy and safety of calcium ionophore during assisted oocyte activation (AOA). This meta-analysis contained randomized controlled trials and prospective observational and retrospective trials.
Yinghua Shan +5 more
doaj +4 more sources
Calcium Ionophore (A23187) Rescues the Activation of Unfertilized Oocytes After Intracytoplasmic Sperm Injection and Chromosome Analysis of Blastocyst After Activation [PDF]
Frontiers in Endocrinology, 2021 Calcium is a crucial factor in regulating the biological behavior of cells. The imbalance of calcium homeostasis in cytoplasm will cause abnormal behavior of cells and the occurrence of diseases.
Ziwen Xu +17 more
doaj +4 more sources
Effect of calcium ionophore (A23187) on embryo development and its safety in PGT cycles [PDF]
Frontiers in Endocrinology, 2023 BackgroundIntracytoplasmic sperm injection (ICSI) has tremendous advantages for resolving the problem of male infertility. However, ICSI fertilization can fail in some patients because of various reasons, primarily because of the failure of oocyte ...
Junya Zhang +19 more
doaj +2 more sources
Comparison of Human Oocyte Activation Between Round-Headed Sperm Injection Followed by Calcium Ionophore Treatment and Normal Sperm Injection in a Patient With Globozoospermia [PDF]
Frontiers in Endocrinology, 2020 Fertilization failure is common in patients with round-headed sperm, a form of globozoospermia. Artificial oocyte activation is able to assist oocyte fertilization after sperm injection in these patients.
Xiangli Niu +3 more
doaj +2 more sources
Effects of calcium Ionophore A23187 on the apoptosis of hepatic stellate cells stimulated by transforming growth factor-β1 [PDF]
Cellular & Molecular Biology Letters, 2018 Background Our previous study showed that during in vitro experiments changes in calcium concentration were associated with apoptosis. We presumed that the calcium ion might play a role as intermediate messenger for apoptosis-related genes.
Yanan Li +5 more
doaj +2 more sources
Anti-Cancer Effects of 3, 3’-Diindolylmethane on Human Hepatocellular Carcinoma Cells Is Enhanced by Calcium Ionophore: The Role of Cytosolic Ca2+ and p38 MAPK [PDF]
Frontiers in Pharmacology, 2019 Purpose: 3,3′-Diindolylmethane (DIM), derived from indole-3-carbinol (I3C) in the Brassica species of cruciferous vegetables, has anticancer effects, but its exact underlying mechanism of action is unknown. We explored the roles of cytosolic free calcium
Yuanyue Jiang +11 more
doaj +2 more sources
Treatment with Calcium Ionophore Improves The Results in Patients with Previous Unsuccessful Attempts at The Fertilization: A Cohort Study [PDF]
International Journal of Fertility and Sterility, 2021 Background: The objective of this study is to evaluate artificial oocyte activation (AOA) with calcium ionophore(CaI) in a subsequent attempt at fertilisation in patients after extremely low or failed fertilisation.
Alberto Tejera +5 more
doaj +2 more sources
Rescuing Fertilization Failure in ICSI: A Narrative Review of Calcium Ionophore Activation, PLCζ Testing, and Embryo Morphokinetics [PDF]
BiomedicinesFertilisation failure following intracytoplasmic sperm injection (ICSI) is a significant challenge in assisted reproductive technology (ART), particularly in the absence of an identifiable cause. Artificial oocyte activation (AOA), typically with calcium
Charalampos Voros +19 more
doaj +2 more sources
Calcium ionophore-activated platelets induce eosinophil extracellular trap formation
Allergology International, 2023 Background: Platelets play a modulatory role in inflammatory response by secreting a vast array of granules and disintegrating into membrane-bound microparticles upon activation.
Myeong Seong Sim +8 more
doaj +3 more sources
Effect of calcium ionophore on unfertilized oocytes after ICSI cycles [PDF]
Iranian Journal of Reproductive Medicine, 2012 Background: Fertilization failure is one of the most problems in assisted reproduction technology (ART). Objective: The aim of this study was the evaluation of oocytes activation by addition of calcium ionophore in unfertilized oocytes in ICSI cycles ...
Maryam Eftekhar +4 more
doaj +1 more source