Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles. [PDF]
J Thromb Haemost, 2022 ACKNOWLEDGEMENTS The authors are indebted to Prof. Edit Buzás MD, PhD (Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary) for the expert discussion on extracellular vesicles. We also thank Ms.
Somodi L +9 more
europepmc +4 more sources
Polyether Ionophore Antibiotics Target Drug-Resistant Clinical Isolates, Persister Cells, and Biofilms [PDF]
Microbiology Spectrum, 2023 Polyether ionophores are complex natural products known to transport various cations across biological membranes. While several members of this family are used in agriculture (e.g., as anti-coccidiostats) and have potent antibacterial activity, they are ...
Malene Wollesen +8 more
doaj +3 more sources
Calcium ionophore improves embryonic development and pregnancy outcomes in patients with previous developmental problems in ICSI cycles [PDF]
BMC Pregnancy and Childbirth, 2022 Background Calcium (Ca2+) ionophores are now mainly considered as efficient treatments for fertilization failure. Recently, its application for rescuing poor embryo development was proposed but still non-routine.
Xiaolei Chen +8 more
doaj +2 more sources
Synthesis and crystal structure of the bis-calcimycin anion–Ni2+ complex [PDF]
ARKIVOC, 2008 La structure aux rayons X du complexe [Ni(calcimycine) 2 ] montre deux conformations essentiellement identiques des deux ligands de la calcimycine dans l'association dimérique, dans cette famille d'ionophores. Dans le complexe du titre, le cation nickel (II) a un environnement de coordination octaédrique O 4 N 2 déformé.
M. Akkurt +5 more
doaj +3 more sources
Frontiers in Microbiology, 2017 Calcimycin is a unique ionophoric antibiotic that is widely used in biochemical and pharmaceutical applications, but the genetic basis underlying the regulatory mechanisms of calcimycin biosynthesis are unclear.
Tiesheng Han, Zhijun Wang
exaly +3 more sources
Ultrastructural Complexity of Nuclear Components During Early Apoptotic Phases in Breast Cancer Cells [PDF]
Analytical Cellular Pathology, 2001 Fractal morphometry was used to investigate the ultrastructural features of the plasma membrane, perinuclear membrane and nuclear chromatin in SK‐BR‐3 human breast cancer cells undergoing apoptosis.
Christian Castelli, Gabriele A. Losa
doaj +2 more sources
Influence of Amino Acid Feeding on Production of Calcimycin and Analogs in Streptomyces chartreusis. [PDF]
Int J Environ Res Public Health, 2021 Streptomyces chartreusis NRRL 3882 produces the polyether ionophore calcimycin and a variety of analogs, which originate from the same biosynthetic gene cluster. The role of calcimycin and its analogs for the producer is unknown, but calcimycin has strong antibacterial activity.
Arend KI, Bandow JE.
europepmc +4 more sources
S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells [PDF]
Molecular Biology of the Cell, 2011 The calcium-binding protein S100A4 is a central mediator of metastasis formation in colon cancer. S100A4 is a target gene of the Wnt/{beta}-catenin pathway, which is constitutively active in the majority of colon cancers.
Wolfgang Walther, Ulrike Stein
exaly +4 more sources
Jurnal Veteriner, 2016 The aim of study was to find out the best concentration and exposure time of calcimycin andionomycin in order to produce parthenogenetic embryos. Female Swiss Webster mice were fisrtlyprimed with Pregnant Mare’s Serum Gonadotropin (PMSG) and Human ...
Wilmientje Marlene Nalley +1 more
doaj +1 more source
Recycling of Overactivated Acyls by a Type II Thioesterase during Calcimycin Biosynthesis in Streptomyces chartreusis NRRL 3882 [PDF]
Applied and Environmental Microbiology, 2018 ABSTRACT Type II thioesterases typically function as editing enzymes, removing acyl groups that have been misconjugated to acyl carrier proteins during polyketide secondary metabolite biosynthesis as a consequence of biosynthetic errors.
Jingdan Liang, Zixin Deng, Zhijun Wang
exaly +3 more sources