The FASEB Journal, Volume 35, Issue 2, February 2021., 2021 Abstract Panton‐Valentine Leukocidin (PVL) is a bicomponent leukotoxin produced by 3%‐10% of clinical Staphylococcus aureus (SA) strains involved in the severity of hospital and community‐acquired infections. Although PVL was long known as a pore‐forming toxin, recent studies have challenged the formation of a pore at the plasma membrane, while its ...
Viola Mazzoleni +4 more
wiley +1 more source
International Journal of Electrochemical Science, 2013 The transport of cadmium and of copper ions across the artificially prepared model phospholipid (PL) membranes on the polycarbonate supports was studied in the present manuscript.
Martina Parisová +4 more
doaj +1 more source
Analytical Cellular Pathology, 2001 Fractal morphometry was used to investigate the ultrastructural features of the plasma membrane, perinuclear membrane and nuclear chromatin in SK‐BR‐3 human breast cancer cells undergoing apoptosis.
Christian Castelli, Gabriele A. Losa
doaj +1 more source
A Novel Hemisynthesis of the 19‐Demethyl Analogue of Calcimycin (or A23187).
ChemInform, 2002 AbstractFor Abstract see ChemInform Abstract in Full Text.
Stéphane Vila +3 more
openaire +1 more source
Mode of action of calcimycin (A 23187). VI. Complexation of transition and heavy metal divalent cations in methanol [PDF]
, 2017 Interaction between calcimycin HA and transition and heavy metal divalent cations M2+ in methanol was studied using potentiometry. Both MA+ and MA2 complexes are formed, except for Pb2+.
J Juillard +3 more
core +1 more source
Characterization of the Biosynthesis Gene Cluster for the Pyrrole Polyether Antibiotic Calcimycin (A23187) in Streptomyces chartreusis NRRL 3882 [PDF]
, 2011 The pyrrole polyether antibiotic calcimycin (A23187) is a rare ionophore that is specific for divalent cations. It is widely used as a biochemical and pharmacological tool because of its multiple, unique biological effects. Here we report on the cloning,
Linquan Bai +6 more
core +1 more source
Mode of action of calcimycin (A 23187). V. Its reactions with monovalent metal cations in a biphasic water-organic solvent system [PDF]
, 2017 Extraction, as a function of the pH, of monovalent cations in water by the bacterial ionophore calcimycin in a butanol-toluene mixture was studied. The various possible equilibria were considered, the equations for the corresponding extraction curves ...
Y Pointud +6 more
core +1 more source
Recycling of overactivated acyls by a type II thioesterase during calcimycin biosynthesis in Streptomyces chartreusis NRRL 3882 [PDF]
, 2018 © 2018 American Society for Microbiology. Type II thioesterases typically function as editing enzymes, removing acyl groups that have been misconjugated to acyl carrier proteins during polyketide secondary metabolite biosynthesis as a consequence of ...
Ian J. Bruce +20 more
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Calcimycin-induced lens epithelial cell apoptosis contributes to cataract formation
Experimental Eye Research, 1995 Previous studies have shown that calcimycin induces cataract in organ culture. To investigate the mechanism of this induction, the viability of lens epithelial cells in calcimycin (calcium ionophore, A23187)-treated rat lenses were examined. During incubation of lenses with 5 microM calcimycin, apoptotic epithelial cells were found after a 2-hr ...
W C, Li +4 more
openaire +2 more sources
Mode of action of calcimycin (A 23187) — II — A study of its interactions ith alkali and alkali-earth cations in methanol-water mixtures [PDF]
, 2017 Interactions between calcimycin (A 23187) and alkali or alklali-earth cations are studied in methanol-water mixtures. Using both potentiometric and spectrométric teenies allows to get formation constants of the various complexes, as well as their ...
C. Tissier +3 more
core +1 more source