Results 11 to 20 of about 2,749 (172)

Increase of Intracellular Zinc Levels Rather Than Zinc Influx Inhibits Interleukin-2 Production in Zinc Supplemented Jurkat Cells. [PDF]

Cell Biochem Funct
ABSTRACT The essential trace element zinc is a well‐known modulator of T cell activation. There have been contradictory findings for the impact of zinc supplementation on T cell activation. In our study, we aimed to analyze IL‐2 production in Jurkat T cells during zinc supplementation in response to different stimuli.
Sobernig CM, Fischer HJ, Rink L, Jakobs J.   +3 more
europepmc   +2 more sources

The Alzheimer's Disease Gene SORL1 Regulates Lysosome Function in Human Microglia. [PDF]

Glia
Main Points The AD gene SORL1 is important for maintaining lysosomal homeostasis in microglia. SORL1 KO hiPSC‐derived microglia show mis‐trafficking of lysosomal enzymes, impaired lysosomal degradation and exocytosis, and changes in neuroimmune responses.
Mishra S, Morshed N, Sidhu SB, Kinoshita C, Stevens B, Jayadev S, Young JE.   +6 more
europepmc   +2 more sources

Effects of 4-Br-A23187 on Bacillus subtilis cells and unilamellar vesicles reveal it to be a potent copper ionophore. [PDF]

Proteomics, 2022
Abstract Ionophores are small molecules or peptides that transport metal ions across biological membranes. Their transport capabilities are typically characterized in vitro using vesicles and single ion species. It is difficult to infer from these data which effects ionophores have on living cells in a complex environment (e.g., culture medium), since ...
Senges CHR, Warmuth HL, Vázquez-Hernández M, Uzun HD, Sagurna L, Dietze P, Schmidt C, Mücher B, Herlitze S, Krämer U, Ott I, Günther Pomorski T, Bandow JE.   +12 more
europepmc   +2 more sources

Investigations on Regulation of MicroRNAs in Rice Reveal [Ca2+]cyt Signal Transduction Regulated MicroRNAs

Frontiers in Plant Science, 2021
MicroRNAs (miRNAs) are critical components of the multidimensional regulatory networks in eukaryotic systems. Given their diverse spectrum of function, it is apparent that the transcription, processing, and activity of the miRNAs themselves, is very ...
Shivani Kansal, Vaishali Panwar, Roseeta Devi Mutum, Saurabh Raghuvanshi   +3 more
doaj   +1 more source

Alternative Benzoxazole Assembly Discovered in Anaerobic Bacteria Provides Access to Privileged Heterocyclic Scaffold

Angewandte Chemie, Volume 134, Issue 32, August 8, 2022., 2022
A novel biosynthetic route to a medically relevant benzoxazole scaffold was discovered in anaerobic bacteria. Genome editing, heterologous expression, and biotransformation studies show that the pathway invokes specialized precursors, backbone assembly, and heterocyclization to form closoxazoles. The biocatalysts involved display synthetic utility, and
Therese Horch, Evelyn M. Molloy, Florian Bredy, Veit G. Haensch, Kirstin Scherlach, Kyle L. Dunbar, Jonathan Franke, Christian Hertweck   +7 more
wiley   +2 more sources

Therapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet-Rich Plasma: A Literature Review. [PDF]

J Cosmet Dermatol
ABSTRACT Background There are exciting advances in the field of exosomes research as a potential regenerative therapy. Platelet‐rich plasma represents an abundant source of exosomes. Aim To present evidence on the use of platelet‐rich plasma‐derived exosomes in dermatology and discuss current technical limitations.
Gupta AK, Wang T, Rapaport JA, Talukder M.   +3 more
europepmc   +2 more sources

Alterations in voltage-sensing of the mitochondrial permeability transition pore in ANT1-deficient cells [PDF]

, 2017
The probability of mitochondrial permeability transition (mPT) pore opening is inversely related to the magnitude of the proton electrochemical gradient. The module conferring sensitivity of the pore to this gradient has not been identified.
A Batarseh, A Dorner, A Echaniz-Laguna, A Lena, A Rasola, A Tikunov, AA Gerencser, AA Gerencser, AD Beavis, AD Beavis, AE Palmer, AM Das, AN Murphy, AP Halestrap, AP Halestrap, AP Halestrap, AP Halestrap, AY Abramov, B Yun, BD Ray, BM Le, C Chinopoulos, C Chinopoulos, C Chinopoulos, C Chinopoulos, C Chinopoulos, C Chinopoulos, C Chinopoulos, C Chinopoulos, C Chinopoulos, C Konrad, C Konrad, CM Palmeira, D Laoudj-Chenivesse, D Vilchez, DG Nicholls, E Fontaine, E Fontaine, E Majima, EA Jonas, F Climent, G Kiss, G Kiss, G Szabadkai, GP McStay, H Kawamata, H Kawamata, IV Perevoshchikova, J Byczkowski, J Doczi, J Lee, J Michejda, J Sileikyte, J Sileikyte, JE Kokoszka, JF Dumas, JP Issartel, JY Jang, KA Lord, KM Broekemeier, KN Alavian, KW Oh, L Azzolin, L Scorrano, M Aureliano, M Bonora, M Bonora, M Klingenberg, M Wysocka-Kapcinska, M Zoratti, MA Menze, MD Linder, MK Bauer, MW Ward, O Eriksson, P Bernardi, P Bernardi, P Bernardi, P Bernardi, P Costantini, P Costantini, PK Smith, R Marcu, RA Neher, S Chalmers, S Kahraman, S Rozen, S Vajda, S Vesce, SS Roy, T Kristian, TR Figueira, V Giorgio, V Petronilli, V Petronilli, V Petronilli, Z Wang   +96 more
core   +5 more sources

In vitro Activation of mouse oocytes through intracellular Ca2+ regulation

Journal of Human Reproductive Sciences, 2020
Background: Ca2+ signaling pathway is suggested to play an essential role in mediating oocyte maturation. Aims: The aim of this study was to evaluate intracellular Ca2+ of resistant immature oocytes that failed to resume meiosis following subsequent in ...
Nining Handayani, Budi Wiweko, Sarah Chairani Zakirah, Arief Boediono   +3 more
doaj   +1 more source

Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21‐mediated ubiquitination/degradation of STAT1 in a GTP binding‐dependent modality

Cancer Communications, Volume 43, Issue 1, Page 123-149, January 2023., 2023
Abstract Background Previous studies have revealed the critical role of transglutaminase 2 (TGM2) as a potential therapeutic target in cancers, but the oncogenic roles and underlying mechanisms of TGM2 in gastric cancer (GC) are not fully understood. In this study, we examined the role and potential mechanism of TGM2 in GC.
Lu Zhang, Qingya Li, Jing Yang, Penghui Xu, Zhe Xuan, Jianghao Xu, Zekuan Xu   +6 more
wiley   +1 more source

Selective and sensitive fluorescence imaging reveals microenvironment-dependent behavior of NO modulators in the endothelial system

Journal of Pharmaceutical Analysis, 2020
Nitric oxide (NO) is a second messenger playing crucial roles in the signaling of a variety of cellular functions. Due to its pathophysiological significance, various NO modulators have been developed to explore NO pathways and some have been used as ...
Ying Dong, Xiao-Rong Li, Jia Li, Yi Zang, Xin Li   +4 more
doaj   +1 more source