Results 11 to 20 of about 2,232 (157)

Calcium Ionophore, Calcimycin, KillsLeishmaniaPromastigotes by Activating Parasite Nitric Oxide Synthase [PDF]

BioMed Research International, 2017
Leishmaniasis is an infectious disease caused by protozoan parasites of the genusLeishmania. There is no vaccine against human leishmaniasis and the treatment of the disease would benefit from a broader spectrum and a higher efficacy of leishmanicidal compounds.
Igor Grekov, António R. Pombinho, Tatyana Kobets, Petr Bartůněk, Marie Lipoldová   +4 more
openaire   +5 more sources

Increase of Intracellular Zinc Levels Rather Than Zinc Influx Inhibits Interleukin-2 Production in Zinc Supplemented Jurkat Cells. [PDF]

Cell Biochem Funct
ABSTRACT The essential trace element zinc is a well‐known modulator of T cell activation. There have been contradictory findings for the impact of zinc supplementation on T cell activation. In our study, we aimed to analyze IL‐2 production in Jurkat T cells during zinc supplementation in response to different stimuli.
Sobernig CM, Fischer HJ, Rink L, Jakobs J.   +3 more
europepmc   +2 more sources

Influence of amino acid feeding on production of calcimycin and analogs in \(\textit {Streptomyces chartreusis}\) [PDF]

, 2021
\(\textit  {Streptomyces chartreusis}\) NRRL 3882 produces the polyether ionophore calcimycin and a variety of analogs, which originate from the same biosynthetic gene cluster. The role of calcimycin and its analogs for the producer is unknown, but calcimycin has strong antibacterial activity.
Arend, Kirstin Isabell (M.Sc.), Bandow, Julia (Prof. Dr. rer. nat.)   +1 more
openaire   +2 more sources

The Alzheimer's Disease Gene SORL1 Regulates Lysosome Function in Human Microglia. [PDF]

Glia
Main Points The AD gene SORL1 is important for maintaining lysosomal homeostasis in microglia. SORL1 KO hiPSC‐derived microglia show mis‐trafficking of lysosomal enzymes, impaired lysosomal degradation and exocytosis, and changes in neuroimmune responses.
Mishra S, Morshed N, Sidhu SB, Kinoshita C, Stevens B, Jayadev S, Young JE.   +6 more
europepmc   +2 more sources

Effects of 4-Br-A23187 on Bacillus subtilis cells and unilamellar vesicles reveal it to be a potent copper ionophore. [PDF]

Proteomics, 2022
Abstract Ionophores are small molecules or peptides that transport metal ions across biological membranes. Their transport capabilities are typically characterized in vitro using vesicles and single ion species. It is difficult to infer from these data which effects ionophores have on living cells in a complex environment (e.g., culture medium), since ...
Senges CHR, Warmuth HL, Vázquez-Hernández M, Uzun HD, Sagurna L, Dietze P, Schmidt C, Mücher B, Herlitze S, Krämer U, Ott I, Günther Pomorski T, Bandow JE.   +12 more
europepmc   +2 more sources

Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles. [PDF]

J Thromb Haemost, 2022
Abstract Background Platelets contain a high amount of potentially active A subunit dimer of coagulation factor XIII (cellular FXIII; cFXIII). It is of cytoplasmic localization, not secreted, but becomes translocated to the surface of platelets activated by convulxin and thrombin (CVX+Thr).
Somodi L, Beke Debreceni I, Kis G, Cozzolino M, Kappelmayer J, Antal M, Panyi G, Bárdos H, Mutch NJ, Muszbek L.   +9 more
europepmc   +2 more sources

Alternative Benzoxazole Assembly Discovered in Anaerobic Bacteria Provides Access to Privileged Heterocyclic Scaffold

Angewandte Chemie, Volume 134, Issue 32, August 8, 2022., 2022
A novel biosynthetic route to a medically relevant benzoxazole scaffold was discovered in anaerobic bacteria. Genome editing, heterologous expression, and biotransformation studies show that the pathway invokes specialized precursors, backbone assembly, and heterocyclization to form closoxazoles. The biocatalysts involved display synthetic utility, and
Therese Horch, Evelyn M. Molloy, Florian Bredy, Veit G. Haensch, Kirstin Scherlach, Kyle L. Dunbar, Jonathan Franke, Christian Hertweck   +7 more
wiley   +2 more sources

Therapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet-Rich Plasma: A Literature Review. [PDF]

J Cosmet Dermatol
ABSTRACT Background There are exciting advances in the field of exosomes research as a potential regenerative therapy. Platelet‐rich plasma represents an abundant source of exosomes. Aim To present evidence on the use of platelet‐rich plasma‐derived exosomes in dermatology and discuss current technical limitations.
Gupta AK, Wang T, Rapaport JA, Talukder M.   +3 more
europepmc   +2 more sources

Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21‐mediated ubiquitination/degradation of STAT1 in a GTP binding‐dependent modality

Cancer Communications, Volume 43, Issue 1, Page 123-149, January 2023., 2023
Abstract Background Previous studies have revealed the critical role of transglutaminase 2 (TGM2) as a potential therapeutic target in cancers, but the oncogenic roles and underlying mechanisms of TGM2 in gastric cancer (GC) are not fully understood. In this study, we examined the role and potential mechanism of TGM2 in GC.
Lu Zhang, Qingya Li, Jing Yang, Penghui Xu, Zhe Xuan, Jianghao Xu, Zekuan Xu   +6 more
wiley   +1 more source

Stimulation of Ca2+‐ATPase Transport Activity by a Small‐Molecule Drug

ChemMedChem, Volume 16, Issue 21, Page 3293-3299, November 5, 2021., 2021
Electric insight: The interaction between the small‐molecule drug CDN1163 and sarcoplasmic reticulum Ca2+−ATPase was investigated by electrical current measurements. It was shown that CDN1163 reversibly binds to the ATPase protein and significantly enhances ATP‐dependent calcium translocation.
Giacomo Sordi, Andrea Goti, Howard S. Young, Ilaria Palchetti, Francesco Tadini‐Buoninsegni   +4 more
wiley   +1 more source