Results 31 to 40 of about 2,232 (157)
Advanced Science, Volume 13, Issue 3, 14 January 2026.Using a dynamic, tri‐culture air‐blood barrier model, this study reveals that macrophage‐mediated transport governs micron‐sized particle translocation under cyclic strain. The process is highly size‐dependent that 2 µm particles are transported by macrophages, 0.2 µm particles diffuse passively, and 5 µm particles are effectively blocked.
Yongjian Li +3 more
wiley +1 more source
X-14885A: An ionophore closely related to calcimycin (A-23187). NMR, thermodynamic, and kinetic studies of cation selectivity [PDF]
, 1989 International audienceX-14885A is an open-chain carboxylic ionophore, recently isolated from a Streptomyces strain. NMR data have shown that the free acid form adopts a pseudocyclic conformation in chloroform, while in the neutral A 2Mg complex a ...
Tissier, C. +11 more
core +1 more source
Health Science Reports, Volume 8, Issue 10, October 2025.ABSTRACT Background and Aims The pathophysiology of drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is complex and poorly understood. Genetic predispositions play a significant role. We aimed to explore the genetic factors and molecular mechanisms driving DRESS, focusing on gene expression, transcription factors (TFs), microRNAs ...
Ahmed I. AbdElneam +8 more
wiley +1 more source
Calcimycin and Related Antibiotics: Calcium/Magnesium Transport Selectivity [PDF]
, 1987 International audienceThermodynamic, spectrophotometric and kinetic data obtained for calcium and magnesium complexation by the natural ionophores calcimycin (A23187) and X 14885 and by the chemically modified ionophore N-methyl-calcimycin are presented ...
Juillard, Jean +3 more
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, 2022 Research and Practice in Thrombosis and Haemostasis, Volume 6, Issue S1, October 2022.
wiley +1 more source
Modulation of Autophagy and Its Effect on Intracellular Mycobacteria by Calcimycin [PDF]
, 2019 Calcium ionophores like Calcimycin are known for their antimicrobial activity in vitro against gram-positive bacteria and fungi but its antimycobacterial effect is in infancy.
Mawatwal, Shradha
core
Discovery and In Vitro Reconstitution of Closoxazole Biosynthesis from Pyxidicoccus fallax
ChemBioChem, Volume 26, Issue 10, May 27, 2025.The myxobacterium Pyxidicoccus fallax is found to be a producer of benzoxazole‐containing natural products named closoxazoles. In vitro studies with the biosynthetic enzymes reveal new insights into the reaction mechanism for closoxazole formation.
Lucia Lernoud +4 more
wiley +1 more source
Mechanistic Insight on the Role of ESAT-6 in Modulating Host Defensive Pathways Through MicroRNA-30a in Mycobacteria Infected Macrophages [PDF]
, 2021 The weaponry possessed by Mycobacterium tuberculosis (M. tb) in the form of immunodominant antigens hijack the host defense system to give a survival advantage to this intracellular fiend, but the mechanism of this control is not entirely known.
Behura, Assirbad
core
Bioinorganic Chemistry and Applications, Volume 2025, Issue 1, 2025.Sarcoplasmic reticulum Ca2+‐ATPase (SERCA) is a key protein involved in calcium homeostasis and the pivotal role of Ca2+ in a plethora of biological activities makes SERCA a powerful biological target. The intertwining between Ca2+ signalling and reactive oxygen species (ROS) has drawn much attention to investigate the photodynamic effect that ...
Gina Elena Giacomazzo +8 more
wiley +1 more source
the role of exo- and endogenous inhibitors [PDF]
, 2011 S100A4 spielt eine zentrale Rolle für die Metastasierung des Dickdarmkrebses. Die Hemmung der S100A4 Expression stellt damit einen vielversprechenden therapeutischen Ansatz dar.
Sack, Ulrike
core +1 more source