A Novel Hemisynthesis of the 19‐Demethyl Analogue of Calcimycin (or A23187).
ChemInform, 2002 AbstractFor Abstract see ChemInform Abstract in Full Text.
Stéphane Vila +3 more
openaire +1 more source
ChemBioChem, Volume 25, Issue 7, April 2, 2024.A convergent synthesis was used to access both enantiomers of the polyether antibiotic routiennocin, and a diastereomeric variant, to probe the biological consequences of altering the naturally configured stereochemistry. Testing these compounds against a broad panel of bacteria and mammalian cells revealed independence of absolute stereochemistry in ...
Søren Lau Borcher Møller +6 more
wiley +1 more source
DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury [PDF]
, 2015 Acute brain lesions induce profound alterations of the peripheral immune response comprising the opposing phenomena of early immune activation and subsequent immunosuppression. The mechanisms underlying this brain-immune signaling are largely unknown. We
Akhisaroglu, Mustafa +13 more
core +3 more sources
International Journal of Microbiology, Volume 2024, Issue 1, 2024.Cellulolytic microorganisms secrete cellulase, which plays a crucial role in the conversion of lignocellulosic biomass into value‐added products with diverse applications in industries, such as biofuel, healthcare, and agriculture. As the world transitions to a bioenergy future, cellulase demand is likely to expand.
Isabel Grace T. Gatpatan +3 more
wiley +1 more source
Cell permeable stapled peptide inhibitor of Wnt signaling that targets β-catenin protein‒protein interactions [PDF]
, 2017 The Wnt signaling pathway plays a critical role in cell proliferation and differentiation, thus it is often associated with diseases such as cancers. Unfortunately, although attractive, developing anti-cancer strategy targeting Wnt signaling has been ...
Bange, Tanja +7 more
core +2 more sources
Preparation of Neurospora crassa mitochondria [PDF]
, 1978 The fungus Neurospora crassa represents a eukaryotic cell with high biosynthetic activities. Cell mass doubles in 2-4 hr during expone ntial growth , even in simple salt media with sucrose as the sole carbon source. The microorgani sm forms a mycelium of
Jacki +11 more
core +2 more sources
Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts. [PDF]
, 2015 AIMS: Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation.
Chandrasekharan, KH +7 more
core +2 more sources
Improved fertilization and implantation rates after non-touch zona pellucida microdrilling of mouse oocytes with a 1.48 μm diode laser beam [PDF]
, 2017 The safety of microdrilling the zona pellucida of moose oocytes with a 1.48 μm diode laser has been investigated by determining the ability of mouse oocytes to fertilize in vitro and develop in vivo.
Delacréaz, G. +6 more
core
Pharmacological strategies for manipulating plant Ca2+ signalling [PDF]
, 2018 Calcium is one of the most pleiotropic second messengers in all living organisms. However, signalling specificity is encoded via spatio-temporally regulated signatures that act with surgical precision to elicit highly specific cellular responses.
Beeckman, Tom +3 more
core +2 more sources
The effects of aB-crystallin on mitochondrial death pathway during hydrogen peroxide induced apoptosis [PDF]
aB-crystallin, a major small heat shock protein, has recently been shown to exert inhibitory effects on apoptosis, while the responsible mechanisms remain largely unknown.
Deng, Gonghua +5 more
core +1 more source