Results 61 to 70 of about 362,318 (287)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Regional economic development policy of cross-border cooperation: improving trends

Aspekti Publìčnogo Upravlìnnâ, 2014
Development of regional cross-border economic cooperation on the national and regional levels become increasingly important for the european integration of Ukraine. When forming the state regional policy, in the field of cross-border economic cooperation
V. F. Lutchak
doaj  

Evolution of the Concept of Cross-Border Cooperation in Russian and Foreign Historiography

RUDN Journal of World History
Despite cross-border cooperation being an object of study in the socio-humanitarian sciences, few studies comprehensively and purposefully overview its genesis, development, and transformation in historiography.
Anastasiia S. Tarasova
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Barrier effect and cross-border cooperation. The Sweden-Norway INTERREG–A territorial effects [PDF]

, 2014
Historic developments that occurred in the last centuries have affected the barrier effect of national borders in Europe and, consequently, the degree and the intensity of the cooperation between neighbouring countries.
Eduardo Medeiros
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Reimagining Cross-Border Cooperation From Indonesia-Malaysia Experiences: A Thematic Literature Review

Journal of ASEAN Studies
The research aimed to explore the scientific discourse of cross-border cooperation in Southeast Asia, particularly on the Indonesia-Malaysia border area.
Sandy Nur Ikfal Raharjo, Hanizah Idris
doaj   +1 more source

Tourism Cooperation Projects In The Cross Border Romanian-Ukrainian Maramures. Vectors For Sustainable Development? [PDF]

, 2012
The tourism cross border cooperation is an integrated model of this type of cooperation, as it is situated at a common point of several cross border fields of activity determined by social and economic phenomena, environmental processes, and territorial ...
Nicolae, Boar, Sorin, Kosinszki
core  

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Territorial Impact Assessment and Cross-Border Cooperation [PDF]

Regional Studies, Regional Science, 2015
Impact Assessment procedures have gained increasing attention from the European Commission (EC), as fundamental tools in providing evidence of the potential impacts of European Union (EU) financed projects/programmes/policies. Yet, only recently, the Territorial Impact Assessment (TIA) of EU directives and Policies have gained a broader support from ...
openaire   +2 more sources