Results 91 to 100 of about 10,534,508 (304)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Mechanisms for similarity matching in disparity measurement

open access: yesFrontiers in Psychology, 2014
Early neural mechanisms for the measurement of binocular disparity appear to operate in a manner consistent with cross-correlation-like processes. Consequently, cross-correlation, or cross-correlation-like procedures have been used in a range of models ...
Ross eGoutcher, Paul B Hibbard
doaj   +1 more source

On the Cross-Correlation of Golomb Costas Permutations

open access: yesIEEE Transactions on Information Theory
In the most interesting case of safe prime powers $q$, Gómez and Winterhof showed that a subfamily of the family of Golomb Costas permutations of $\{1,2,\ldots,q-2\}$ of size $φ(q-1)$ has maximal cross-correlation of order of magnitude at most $q^{1/2}$.
Huaning Liu, Arne Winterhof
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A semi-automatic approach to identify first arrival time: the Cross-Correlation Technique

open access: yesEarth Sciences Research Journal, 2014
The high-quality interpretation of seismic refraction data depends on the accurate and reliable identification of the first arrival times. First arrivals can be identified on a graphic or image by conventional picking, but this process depends on ...
Mustafa Senkaya, Hakan Karslı
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

FAULT LOCATION ON A DISTRIBUTION FEEDER USING FAULT GENERATED HIGH FREQUENCY CURRENT SIGNATURES

open access: yesASEAN Journal on Science and Technology for Development, 2017
This paper describes how the fault generated travelling waves detected in the current signals at a single location on a distribution feeder can be used for fault location.
Hashim Hizam, P.A. Crossley
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

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