Results 61 to 70 of about 374,817 (289)

Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents [PDF]

, 2012
An iron-catalysed, hydride-mediated reductive cross-coupling reaction has been developed for the preparation of alkanes. Using a bench-stable iron(II) pre-catalyst, reductive cross-coupling of vinyl iodides, bromides and chlorides with aryl-and alkyl ...
Greenhalgh, Mark D., Le Bailly, Bryden A. F., Thomas, Stephen P.   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Synergistic approach to polycycles through Suzuki–Miyaura cross coupling and metathesis as key steps

Beilstein Journal of Organic Chemistry, 2018
This account provides an overview of recent work, including our own contribution dealing with Suzuki–Miyaura cross coupling in combination with metathesis (or vice-versa). Several cyclophanes, polycycles, macrocycles, spirocycles, stilbenes, biaryls, and
Sambasivarao Kotha, Milind Meshram, Chandravathi Chakkapalli   +2 more
doaj   +1 more source

Modification of Purine and Pyrimidine Nucleosides by Direct C-H Bond Activation

Molecules, 2015
Transition metal-catalyzed modifications of the activated heterocyclic bases of nucleosides as well as DNA or RNA fragments employing traditional cross-coupling methods have been well-established in nucleic acid chemistry.
Yong Liang, Stanislaw F. Wnuk
doaj   +1 more source

Developing and Understanding Iridium-Catalysed Arene Borylation [PDF]

, 2011
Iridium catalysed C-H borylation has moved from an interesting observation to an efficient catalytic reaction. This work has developed and improved upon some of the key issues associated with the methodology.
HARRISSON, PETER
core  

Catalytic Enantioselective Cross-Couplings of Secondary Alkyl Electrophiles with Secondary Alkylmetal Nucleophiles: Negishi Reactions of Racemic Benzylic Bromides with Achiral Alkylzinc Reagents [PDF]

, 2012
We have developed a nickel-catalyzed method for the asymmetric cross-coupling of secondary electrophiles with secondary nucleophiles, specifically, stereoconvergent Negishi reactions of racemic benzylic bromides with achiral cycloalkylzinc reagents.
Arp F. O., Brunner H., Caeiro J., Choi J., Christopher J. Cordier, Dai X., Fischer C., Glasspoole B. W., Glorius F., Gregory C. Fu, Han C., Hargaden G. C., Hayashi T., Jana R., Jones G. D., Joshi-Pangu A., Jörg T. Binder, Kikushima K., Lin X., Lou S., Lou S., Lundin P. M., Malosh C. F., McCann L. C., Negishi E.-i., Nishiyama H., Oelke A. J., Phapale V. B., Rosen B. M., Rudolph A., Schmidt T., Smith S. W., Smith S. W., Son S., Tamao K., Tsuji T., Wilsily A., Yang C.-T., Zultanski S. L.   +38 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo

Nature Communications, 2017
Coupling synthetic biology and chemical reactions in cells is a challenging task. The authors engineer bacteria capable of generating bromo-metabolites, develop a mild Suzuki-Miyaura cross-coupling reaction compatible with cell growth and carry out the ...
Sunil V. Sharma, Xiaoxue Tong, Cristina Pubill-Ulldemolins, Christopher Cartmell, Emma J. A. Bogosyan, Emma J. Rackham, Enrico Marelli, Refaat B. Hamed, Rebecca J. M. Goss   +8 more
doaj   +1 more source

Cross-Coupling Reaction with Lithium Methyltriolborate

Molecules, 2012
We newly developed lithium methyltriolborate as an air-stable white solid that is convenient to handle. The good performance of this triolborate for metal-catalyzed bond-forming reactions was demonstrated in palladium-catalyzed cross-coupling reactions ...
Norio Miyaura, Hajime Ito, Yasunori Yamamoto, Kazuya Ikizakura   +3 more
doaj   +1 more source

Preparation, Structure, and Reactivity of Nonstabilized Organoiron Compounds. Implications for Iron-Catalyzed Cross Coupling Reactions [PDF]

, 2008
A series of unprecedented organoiron complexes of the formal oxidation states −2, 0, +1, +2, and +3 is presented, which are largely devoid of stabilizing ligands and, in part, also electronically unsaturated (14-, 16-, 17- and 18-electron counts ...
Fürstner, A., Goddard, R., Krause, H., Lehmann, C., Martin, R., Seidel, G.   +5 more
core   +1 more source