Results 41 to 50 of about 374,817 (289)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Cu(I)-catalysed chemo-, regio-, and stereoselective radical 1,2-carboalkynylation with two different terminal alkynes

Nature Communications
Transition-metal-catalysed asymmetric multicomponent reactions with two similar substrates often suffer from the lack of strategies to control the chemo-, regio-, and stereoselectivity of these substrates due to the close similarity in the chemical ...
Jun-Qian Bian, Li Qin, Li-Wen Fan, Jiajia Fu, Yong-Feng Cheng, Yu-Feng Zhang, Qiao Song, Peng-Fei Wang, Zhong-Liang Li, Qiang-Shuai Gu, Peng Yu, Jun-Bin Tang, Xin-Yuan Liu   +12 more
doaj   +1 more source

Pentaquark baryon production from photon-neuteron reactions

, 2003
Extending the hadronic Lagrangians that we recently introduced for studying pentaquark $\Theta^+$ baryon production from meson-proton, proton-proton, and photon-proton reactions near threshold to include the anomalous interaction between $\gamma$ and $K^*
Arndt, Arndt, Barmin, Barth, C.M. Ko, Cahn, Chen, Chen, Chung, Csikor, Davidson, Diakonov, Garlson, Garlson, Haberzettl, Hagiwara, Haidenbauer, Hyoto, Jaffe, Janssen, Karliner, Kim, Ko, Ko, Kubarovsky, Li, Lin, Lin, Liu, Liu, Liu, Matheus, Nakano, Nakayama, Nam, Nussinov, Oh, Oh, Ohta, Sasaki, Stancu, Stepanyan, Thomas, W. Liu, Zhao, Zhao, Zhu   +46 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Reluctant Cross-Metathesis Reactions: The Highly Beneficial Effect of Microwave Irradiation [PDF]

, 2007
carbene complexes ; catalysis ; cross coupling ; metathesis ; olefinationInternational audienceThe beneficial effect of microwave irradiation versus classical thermal conditions is demonstrated through a series of comparative cross-metathesis ...
Boddaert, Thomas, Coquerel, Yoann, Michaut, Antoine, Rodriguez, Jean   +3 more
core   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Magnetically Recoverable Nanoparticulate Catalysts for Cross-Coupling Reactions: The Dendritic Support Influences the Catalytic Performance

Nanomaterials, 2021
Carbon-carbon cross-coupling reactions are among the most important synthetic tools for the preparation of pharmaceuticals and bioactive compounds. However, these reactions are normally carried out using copper, phosphines, and/or amines, which are ...
Nina V. Kuchkina, Svetlana A. Sorokina, Alexey V. Bykov, Mikhail G. Sulman, Lyudmila M. Bronstein, Zinaida B. Shifrina   +5 more
doaj   +1 more source

Coupling and higher-order effects in the 12C(d,p)13C and 13C(p,d)12C reactions

, 2005
Coupled channels calculations are performed for the 12C(d,p)13C and 13C(p,d)12C reactions between 7 and 60 MeV to study the effect of inelastic couplings in transfer reactions.
F. Delaunay, F. M. Nunes, G. R. Satchler, M. B. Tsang, W. G. Lynch   +4 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source