Results 21 to 30 of about 90,097 (255)
Pd-catalyzed formal Mizoroki–Heck coupling of unactivated alkyl chlorides
Nature Communications, 2021 The use of alkyl chlorides in Pd-catalyzed Mizoroki–Heck coupling reactions remains an unsolved problem despite their significant synthetic potential. Here, the authors show that alkyl chlorides can efficiently participate in Mizoroki–Heck cross-coupling
Geun Seok Lee +2 more
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Synthesis of chiral germanium center enabled by poly-deborylative alkylation and desymmetrization
Nature CommunicationsChiral germanium centers are historically undervalued due to their extremely limited synthetic accessibility. Although germanium shares similar chemical properties with silicon, synthesizing chiral germanium centers proves significantly more challenging.
Ke Wang, Xin-Yuan Liu, Zhe Dong
doaj +1 more source
Well-Defined Pre-Catalysts in Amide and Ester Bond Activation
Molecules, 2019 Over the past few decades, transition metal catalysis has witnessed a rapid and extensive development. The discovery and development of cross-coupling reactions is considered to be one of the most important advancements in the field of organic synthesis.
Sandeep R. Vemula +2 more
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The Hiyama Cross‐Coupling Reaction: New Discoveries [PDF]
The Chemical Record, 2016 AbstractIn this account recent developments in the Hiyama cross‐coupling reaction from 2010 up today are presented. The most important methodology involves formation of biaryl systems by using aryl bromides or iodides and aryl trialkoxy silanes: other variants are far less studied.
Foubelo, Francisco +2 more
openaire +3 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Nature CommunicationsThe (hetero)aryl sulfoximines are important structures for developing bioactive molecules, whose synthesis relies on oxidation of (hetero)aryl sulfilimines. However, asymmetric approaches for assembling (hetero)aryl sulfilimines are still rare.
Mingchuang He +4 more
doaj +1 more source
Mechanistic Insights into Nickamine-catalyzed Alkyl-Alkyl Cross-coupling Reactions
CHIMIA, 2014 Within the last decades the transition metal-catalyzed cross-coupling of non-activated alkyl halides has significantly progressed. Within the context of alkyl-alkyl cross-coupling, first row transition metals spanning from iron, over cobalt ...
Jan Breitenfeld, Xile Hu
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Nature CommunicationsTransition-metal-catalysed asymmetric multicomponent reactions with two similar substrates often suffer from the lack of strategies to control the chemo-, regio-, and stereoselectivity of these substrates due to the close similarity in the chemical ...
Jun-Qian Bian +12 more
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