Results 51 to 60 of about 5,964,900 (273)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Authentication in the Internet of Medical Things: Taxonomy, Review, and Open Issues
Applied Sciences, 2022 The Internet of Medical Things (IoMT) has revolutionized the world of healthcare by remotely connecting patients to healthcare providers through medical devices connected over the Internet.
Norah Alsaeed, Farrukh Nadeem
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
A blockchain-based lightweight authentication and key agreement scheme for internet of vehicles
Connection Science, 2022 The Internet of Vehicles is deployed in an open environment, and protecting its security and data privacy is the challenge. Carrying out the Internet of Vehicles secure authentication before interaction of information is an important part of ensuring the
Jing Zheng +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Study of cross-domain identity authentication in SOA environment
网络与信息安全学报, 2016 For the network nowadays becoming more and more complex,the SOA environment has the properties of heterogeneous and multiple domain.A trust management scheme was proposed based on the fuzzy theory,and a cross-domain identity authentication in SOA was ...
Jing-jing GUO +3 more
doaj +3 more sources
Selection of EAP-authentication methods in WLANs [PDF]
, 2007 IEEE 802.1X is a key part of IEEE802.11i. By employing Extensible Authentication Protocol (EAP) it supports a variety of upper layer authentication methods each with different benefits and drawbacks.
Owens, TJ, Ali, KM
core +4 more sources