Results 111 to 120 of about 10,849,876 (337)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
MODELLING 2X2 CROSS-OVER DESIGNS WITH CARRY-OVER EFFECT FOR BINARY RESPONSES
Journal of Research in Medical Sciences, 2003 In Parallel designs which each patient receives only one treatment we need a large number of patients for assessing treatment effects. Cross-over trials are Known as longitudinal studies.In cross-over trials each patient is his or her own control and ...
H JAHANI HASHEMI +4 more
doaj
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Perspective (Institute for Christian Studies)
, 2014 Errata Note: Dettloff, Dean. "Cynics in the Face of Apocalypse." Perspective 48, no. 2 (Sept 2014): 5. The first two sentences of paragraph 5 should read: To combat modern cynicism, Sloterdijk suggests returning to the figure of Diogenes, emblematic of ...
Ratzlaff, Caleb +9 more
core
On the care and feeding of a gift horse: the recurrent cost problem as the result of biased project design [PDF]
, 1983 African Studies Center Working Paper No. 69INTRODUCTION: Recently, the distinction between the "capital cost" and the "recurrent cost" of a development project has received substantial attention among practitioners of development economics as a result of
Over, A. Mead, Jr.
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Is the Over-Education Wage Penalty Permanent? [PDF]
Much has been written about the impact of over-education on wages using cross-sectional data, although there have been few studies that analyse the returns to over-education in a dynamic setting.
Steven McIntosh, Joanne Lindley
core +1 more source