Results 91 to 100 of about 10,849,876 (337)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Fifteen-Year Prospective Analysis of Television Viewing and Adiposity in African American and Caucasian Men and Women

open access: yesSAGE Open, 2015
There are limited data from long-term prospective studies on the association between television (TV) viewing and obesity. We investigated this association between TV viewing and body mass index (BMI) and waist circumference (WST) over 15 years on 3,269 ...
Chung-Yu Chen   +9 more
doaj   +1 more source

Knowledge and beliefs about the Red Cross: Perspectives of community members and Red Cross workers in San Ramón, Alajuela, Costa Rica

open access: yesCuadernos de investigación UNED, 2016
In Costa Rica, the Red Cross provides most pre-hospital emergency care and transport. Very few studies have investigated extra-hospital emergency care in Costa Rica so this study aimed to fill this gap through interviews with community members, surveys ...
Tela Ebersole, Anabelle Alfaro Obando
doaj   +1 more source

A Cross-Sectional Study of Cannabidiol Users

open access: yesCannabis and Cannabinoid Research, 2018
Introduction: Preclinical and clinical studies suggest that cannabidiol (CBD) found in Cannabis spp. has broad therapeutic value. CBD products can currently be purchased online, over the counter and at Cannabis-specific dispensaries throughout most of ...
Jamie Corroon, Joy A. Phillips
semanticscholar   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

The Reciprocal Relationship Between Gratitude and Life Satisfaction: Evidence From Two Longitudinal Field Studies

open access: yesFrontiers in Psychology, 2019
Gratitude and life satisfaction are associated with several indicators of a good life (e.g., health, pro-social behavior, and relationships). However, how gratitude and life satisfaction relate to each other over time has remained unknown until now ...
Wenceslao Unanue   +7 more
doaj   +1 more source

Palladium-Catalyzed Suzuki-Miyaura Cross-coupling Reactions Employing Dialkylbiaryl Phosphine Ligands

open access: yesAccounts of Chemical Research, 2008
Conspectus The cores of many types of polymers, ligands, natural products, and pharmaceuticals contain biaryl or substituted aromatic structures, and efficient methods of synthesizing these structures are crucial to the work of a broad spectrum of ...
Rúben Martín, S. Buchwald
semanticscholar   +1 more source

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