Results 121 to 130 of about 6,630,927 (326)

Bivalent Vaccine Effectiveness Against Type-Specific HPV Positivity: Evidence for Cross-Protection Against Oncogenic Types Among Dutch STI Clinic Visitors

Journal of Infectious Diseases, 2017
In this cross-sectional study among vaccine-eligible female sexually transmitted infection clinic visitors, high vaccine effectiveness of the bivalent vaccine against the vaccine types HPV-16/18 was demonstrated and significant cross-protection against ...
P. Woestenberg, A. King, B. V. van Benthem, R. Donken, Suzan Leussink, F. R. van der Klis, H. D. de Melker, M. V. D. van der Sande, C. Hoebe, J. Bogaards, D R A D S J M J H P J A R C H M J F S P R D K S I P Adema Buist-Arkema Beerens Luijt Meijer Schirm Pee, D. Adema, R. Buist-Arkema, A. Beerens, D. Luijt, S. Meijer, J. Schirm, M. Peeters, J. Rossen, H. Verbakel, P. van Esch, J. Verweij, A. A. van der Eijk, R. Huisman, C. Kerkhof, H. Korff, M. Schutten, J. Velzing, F. Verduyn-Lunel, S. Lakbiach, P. van Rosmalen, R. Schuurman, D. Abma, K. Adams, S. Bruisten, I. Linde, P. Oostvogel, C. Touwen, W. Vermeulen, A. Brink, J. Nelissen, P. Wolffs, N. Duijvendijk, P. Schneeberger, M. Dinnissen van Poppel, W. Melchers, Y. Poort, M. Hooghiemstra, H. Huisman, J. Weel, F. Bosma, F. Geeraedts, I. Polman, P. van Goor, M. Wolfhagen, C. de Mooij, E. van Koolwijk, M. Peters, C. Swanink, R. Tiemessen, T. van Zwet, J. Janssen, M. Pelsers, W. D. de Waal, G. Aalfs, J. Kiewiet, P. Sanders, H. van Buel-Bruins, C. van Bokhoven-Rombouts, P. Cornelissen, M. Kersten, C. van Ruitenbeek, I. Molenaar, E. Doorn, L. Masthoff, E. Pannekoek, V. Sigurdsson, M. Bugter, H. Götz, M. Illidge-Onder de Linden, M. Mattijssen, J. Stam, E. Swaders, F. de Groot, F. Postma, E. Brouwers, A. Niekamp, M. Smit, A. Botraby, D. Bukasa, C. de Haan, P. Hut-van Vliet, T. Taconis, M. de Graas, I. Hondelink, C. Kampman, A. Gelissen-Hansen, I. de Koning, H. V. van Kruchten, M. van de Pas, H. Fennema, T. Heijman, A. Hogewoning, A. van Leeuwen, M. van Rooijen, F. Neienhuijsen, M. Pelgrim   +106 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage

Emerging Microbes and Infections
The H5N1 subtype highly pathogenic avian influenza virus (HPAIV) reveals high variability and threatens poultry production and public health. To prevent the spread of H5N1 HPAIV, we developed an H5N1 virus-like particle (VLP) vaccine based on the insect ...
Dexin Kong, Yanjuan He, Jiaxin Wang, Lanyan Chi, Xiang Ao, Hejia Ye, Weihong Qiu, Xiutong Zhu, Ming Liao, Huiying Fan   +9 more
doaj   +1 more source

A New Mechanistic Model for Viral Cross Protection and Superinfection Exclusion

Frontiers in Plant Science, 2018
Plants pre-infected with a mild variant of a virus frequently become protected against more severe variants of the same virus through the cross protection phenomenon first discovered in 1929.
Xiaofeng Zhang, Shaoyan Zhang, Q. Guo, Rong Sun, T. Wei, F. Qu   +5 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Tobamovirus Cross Protection Using a Potexvirus Vector

Virology, 1996
Cross protection is the ability of one virus to prevent or delay infection by a related challenge virus. To examine this phenomena, a potato X potexvirus (PVX) vector (Chapman et al., 1992, Plant J. 2, 549) was used to systemically express the tobacco mosaic tobamovirus (TMV) coat protein (CP) open reading frame in Nicotiana benthamiana. PVX constructs
openaire   +2 more sources

Stable and Broad Spectrum Cross-Protection Against Pepino Mosaic Virus Attained by Mixed Infection

Frontiers in Plant Science, 2018
While recent pepino mosaic virus (PepMV; species Pepino mosaic virus, genus Potexvirus, family Alphaflexiviridae) epidemics seem to be predominantly caused by isolates of the CH2 strain, PepMV epidemics in intensive tomato crops in Spain are caused by ...
J. Agüero, C. Gómez‐Aix, R. Sempere, J. García-Villalba, Jorge García-Núñez, Y. Hernando, M. Aranda   +6 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Mathematical model of plant-virus interactions mediated by RNA interference [PDF]

, 2016
Cross-protection, which refers to a process whereby artificially inoculating a plant with a mild strain provides protection against a more aggressive isolate of the virus, is known to be an effective tool of disease control in plants.
Allen, Andreasen, Beachy, Bendahmane, Bergua, Bernstein, Buckee, Buckee, Burdon, Caplen, Castillo-Chavez, Chan, Chowda Reddy, Cisternas, Ciupe, Dietz, Escobar, Ferguson, Ferreira, Frank, Frazer, G. Neofytou, Gal-On, Gog, Gomes, Gupta, Gupta, Gupta, Gutierrez, Hammond, Heesterbeek, Heinen, Hethcote, Himber, Hinrichs, Irwin, Jeger, K.B. Blyuss, Kawakami, Kirtani, Kryazhimskiy, Kuntz, Lalonde, Lee, Levin, Liang, Lipsitch, Madden, Malapi-Nelson, Mauck, Melnyk, Moreno-Delafuente, Neofytou, Opalka, Paine, Pennazio, Perelson, Perelson, Pruss, Pumplin, Purcell, Raja, Ratcliff, Recker, Roossinck, Savary, Sijen, Silva, Soifer, Takeshita, Takeshita, Tian, Tridane, van den Bosch, van den Driessche, Wan, Wassenegger, Waterhouse, Wege, Wodarz, Y.N. Kyrychko, Zhang, Zhang, Zhang, Zhang, Zhou, Zvereva   +86 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source