Results 131 to 140 of about 621,864 (351)

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Chimeric hemagglutinin split vaccines elicit broadly cross-reactive antibodies and protection against group 2 influenza viruses in mice

, 2023
Eduard Puente‐Massaguer, Kirill Vasilev, A. Beyer, Madhumathi Loganathan, Benjamin Francis, Michael J. Scherm, Guha Asthagiri Arunkumar, Irene González‐Domínguez, Xueyong Zhu, Ian A. Wilson, Lynda Coughlan, Weina Sun, Peter Palese, Florian Krammer   +13 more
openalex   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Prämunisierung (cross protection) als neue Strategie zur Bekämpfung von Phytoplasmosen im Obstbau am Beispiel der Apfeltriebsucht [PDF]

, 2016
Cross-Protection, ein Verfahren in dem Pflanzen durch Vorinfektion mit einem avirulenten Erregerstamm geschützt werden sollen, wurde als neue Methode zur Bekämpfung der Apfeltriebsucht erprobt.
Jelkmann, Wilhelm, Schneider, Bernd
core  

The effects of symmetry on the dynamics of antigenic variation

, 2012
In the studies of dynamics of pathogens and their interactions with a host immune system, an important role is played by the structure of antigenic variants associated with a pathogen.
A Fässler, A Marcello, B Adams, B Fiedler, C Jones, C Newbold, C Stockdale, CA Pinto, CMR Turner, CO Buckee, CO Buckee, DG Aronson, DJ Smith, DL Martin, H Farkas, I Stewart, IM Rouzine, JD Barry, JD Murray, JHP Dawes, JL Mitchell, JL Muñoz-Jordán, JR Gog, JW Swift, KA Lythgoe, KB Blyuss, Konstantin B. Blyuss, KW Deitsch, LJ Abu-Raddad, LM Pecora, M Dellnitz, M Golubitsky, M Golubitsky, M Golubitsky, M Golubitsky, M Recker, M Recker, M Recker, M Recker, M Recker, MGM Gomes, MJ Gardner, O Bagasra, P Ashwin, P Ashwin, P Borst, P De Leenheer, P Hagblom, P Minaev, PL Buono, R Antia, S Gupta, S Gupta, S Gupta, S Kyes, S Lutenschlager, SA Frank, SA Frank, SH Strogatz, V Calvez, Y Jiang, Z Agur   +61 more
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

A chimeric strain of porcine reproductive and respiratory syndrome virus 2 derived from HP-PRRSV and NADC30-like PRRSV confers cross-protection against both strains

Veterinary Research
Porcine reproductive and respiratory syndrome (PRRS) is one of the most significant swine viral infectious diseases worldwide. Vaccination is a key strategy for the control and prevention of PRRS.
Yang Li, Yumiao Wang, Xiuxiu Pei, Shao Chen, Yang Jing, Yongshuai Wu, Zhiqian Ma, Zhiwei Li, Zifang Zheng, Yingtong Feng, Lele Xu, Xiao Liu, Xuyang Guo, Haixue Zheng, Shuqi Xiao   +14 more
doaj   +1 more source

Heartwater surveillance in Guadeloupe: a model of partnership between research and surveillance for the Caribbean [PDF]

, 2012
Heartwater, a tick-borne disease of ruminants transmitted by Amblyomma ticks is present in 3 Caribbean islands: Guadeloupe, Marie-Galante and Antigua, representing a threat for neighboring islands and North America.
Faverjon, Céline, Gerbier, Guillaume, Laurent, Marion, Lefrançois, Thierry, Pradel, Jennifer, Redon, Jean-Marc, Teissier, R., Vachiery, Nathalie   +7 more
core  

A Burkholderia pseudomallei Outer Membrane Vesicle Vaccine Provides Cross Protection against Inhalational Glanders in Mice and Non-Human Primates [PDF]

, 2017
Sarah M. Baker, Christopher J.H. Davitt, Natalya I. Motyka, Nicole Kikendall, Kasi Russell‐Lodrigue, Chad J. Roy, Lisa A. Morici   +6 more
openalex   +1 more source

Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock, Jin Nakahara, Becky Parks, Kerstin Allen, Sami Fam   +4 more
wiley   +1 more source