Results 141 to 150 of about 6,630,927 (326)

Llama-Derived Single Domain Antibodies to Build Multivalent, Superpotent and Broadened Neutralizing Anti-Viral Molecules [PDF]

, 2011
For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) against the trimeric envelope proteins of Respiratory Syncytial Virus (
A Forsman, A Trkola, AB Bakker, AI Wandeler, Anna Hultberg, AR Fooks, B García-Barreno, B Serruys, Bert Schepens, C Hamers-Casterman, C. Theo Verrips, D Saerens, DJ Schofield, E De Genst, Eric Kremer, H Bourhy, H Wu, Hans J. de Haard, I Le Roux, J Sheldon, JA Beeler, JA López, JA Montaño-Hirose, JE Crowe, JM van der Vaart, Joris Schillemans, José A. Melero, JP DeVincenzo, JS Klein, JS Rudge, K Coppieters, KE Conrath, L Garaicoechea, Lorena Itatí Ibañez, M Throsby, Maria Gonzalez-Pajuelo, Michael Saunders, Mireille Koenders, MM Harmsen, Nigel J. Temperton, NJ Temperton, Peter Vanlandschoot, PM Colman, RC Roovers, Robin A. Weiss, S Johnson, SJ Wu, Steven Van Gucht, T Corral, TJ Wiktor, Valérie Rosseels, Xavier Saelens   +51 more
core   +8 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Latent gammaherpesvirus 68 infection induces distinct transcriptional changes in different organs [PDF]

, 2013
Previous studies identified a role for latent herpesvirus infection in cross-protection against infection and exacerbation of chronic inflammatory diseases. Here, we identified more than 500 genes differentially expressed in spleens, livers, or brains of
Canny, Susan P, Goel, Gautam, Reese, Tiffany A, Virgin, Herbert W, Xavier, Ramnik, Zhang, Xin   +5 more
core   +2 more sources

An Improved Inactivated Influenza Vaccine with Enhanced Cross Protection

Frontiers in Immunology, 2018
Current inactivated influenza vaccines are strain-specific and poorly effective against variant or mismatched viruses. They are standardized based on their hemagglutinin (HA) or ability to induce strain-specific hemagglutination inhibition (HAI ...
Y. Ni, Jianhua Guo, Debra D. Turner, I. Tizard   +3 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Prämunisierung (cross protection) als neue Strategie zur Bekämpfung von Phytoplasmosen im Obstbau am Beispiel der Apfeltriebsucht [PDF]

, 2016
Cross-Protection, ein Verfahren in dem Pflanzen durch Vorinfektion mit einem avirulenten Erregerstamm geschützt werden sollen, wurde als neue Methode zur Bekämpfung der Apfeltriebsucht erprobt.
Jelkmann, Wilhelm, Schneider, Bernd
core  

A Burkholderia pseudomallei Outer Membrane Vesicle Vaccine Provides Cross Protection against Inhalational Glanders in Mice and Non-Human Primates

Vaccines, 2017
Burkholderia mallei is a Gram-negative, non-motile, facultative intracellular bacillus and the causative agent of glanders, a highly contagious zoonotic disease. B.
Sarah M. Baker, C. Davitt, Natalya I. Motyka, Nicole Kikendall, K. Russell-Lodrigue, C. Roy, L. Morici   +6 more
semanticscholar   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source