Results 111 to 120 of about 942,688 (340)

Clinical azole cross-resistance in Candida parapsilosis is related to a novel MRR1 gain-of-function mutation [PDF]

, 2022
Joana Branco, Adam P. Ryan, Ana P. Silva, Geraldine Butler, Isabel M. Miranda, Acácio G. Rodrigues   +5 more
openalex   +1 more source

Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors. [PDF]

, 2014
BackgroundIn 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether decitabine increased expression of ...
A Kumari, AS Yang, C Festuccia, C Zeller, CA Stidley, CJ Piyathilake, D Ma, D Matei, D Shang, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DJ Stewart, DW Shen, E Gordian, E San Jose-Eneriz, EA Braga, F Crea, F Fang, H Iwata, H Kantarjian, H Kroeger, HM Kantarjian, J Charlet, J Shia, JA Plumb, JP Issa, JP Issa, JS Kim, K Ghoshal, K Onda, K Ramachandran, K Tikoo, KY Tse, L Ding, L Rothem, MA Kane, ML Orta, NH Nabilsi, R Zhao, RH Finnell, S Fu, S Vijayaraghavalu, SB Baylin, SS Muerkoster, T Tanaka, TB Lee, VF Chekhun, X Chang, XJ Liang, Y Li, Y Oki, Y Zhang, ZG Liu   +55 more
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Environmental stress responses in Lactococcus lactis [PDF]

, 1999
Bacteria can encounter a variety of physical conditions during their life. Bacterial cells are able to survive these (often adverse) conditions by the induction of specific or general protection mechanisms. The lactic acid bacterium Lactococcus lactis is
Kok, Jan,, Sanders, Jan Willem,, Venema, Gerard,   +2 more
core   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis

Frontiers in Medicine
Clofazimine (CFZ) and bedaquiline (BDQ) are currently used for the treatment of multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) strains.
Md Mahmudul Islam, Md Mahmudul Islam, Md Mahmudul Islam, Md Mahmudul Islam, Md Mahmudul Islam, Md Shah Alam, Md Shah Alam, Md Shah Alam, Md Shah Alam, Zhiyong Liu, Zhiyong Liu, Zhiyong Liu, Zhiyong Liu, Zhiyong Liu, Mst Sumaia Khatun, Mst Sumaia Khatun, Mst Sumaia Khatun, Mst Sumaia Khatun, Buhari Yusuf, Buhari Yusuf, Buhari Yusuf, Buhari Yusuf, H. M. Adnan Hameed, H. M. Adnan Hameed, H. M. Adnan Hameed, H. M. Adnan Hameed, Xirong Tian, Xirong Tian, Xirong Tian, Xirong Tian, Chiranjibi Chhotaray, Rajesh Basnet, Rajesh Basnet, Rajesh Basnet, Rajesh Basnet, Haftay Abraha, Haftay Abraha, Haftay Abraha, Haftay Abraha, Xiaofan Zhang, Xiaofan Zhang, Xiaofan Zhang, Xiaofan Zhang, Shahzad Akbar Khan, Shahzad Akbar Khan, Shahzad Akbar Khan, Shahzad Akbar Khan, Shahzad Akbar Khan, Cuiting Fang, Cuiting Fang, Cuiting Fang, Cuiting Fang, Chunyu Li, Chunyu Li, Chunyu Li, Chunyu Li, Sohel Hasan, Shouyong Tan, Shouyong Tan, Nanshan Zhong, Nanshan Zhong, Nanshan Zhong, Jinxing Hu, Jinxing Hu, Tianyu Zhang, Tianyu Zhang, Tianyu Zhang, Tianyu Zhang   +67 more
doaj   +1 more source

Phenotypic expression of resistance to penicillinase-stable beta-lactams in Staphylococcus aureus: growth rate, cross wall morphogenesis, and cell division cycle [PDF]

, 1982
F Rozgonyi
openalex   +1 more source

Prevalence of doravirine cross-resistance in HIV-infected adults who failed first-line ART in China, 2014–18 [PDF]

, 2022
Zhuoqun Sun, Yun Lan, Shujia Liang, Jing Wang, Mingjian Ni, Xia Zhang, Fengting Yu, Meiling Chen, Hanxi Zhang, Liting Yan, Weiping Cai, Guanghua Lan, Ye Ma, Fujie Zhang   +13 more
openalex   +1 more source

Synergistic effect of the homologous PB1–NA gene constellation in Influenza A virus reassortants: Evaluation and characterization of reassortant influenza variant viruses cross-resistant to influenza Neuraminidase Inhibitors [PDF]

, 2016
This project aims to elucidate the functional impact of specific mutation induced changes in the NA and PB1 genes on the viral fitness and cross-resistance profile of A(H1N1)pdm09 viruses.info:eu-repo/semantics ...
Louro, João, Rebelo-de-Andrade, Helena
core