Results 61 to 70 of about 21,407 (216)

Unraveling bortezomib resistance in multiple myeloma: insights from RNA-Seq and PI3K/mTOR pathway analysis

Journal of Biological Research
Multiple Myeloma (MM), characterized by abnormal plasma cell proliferation, lacks curative treatment due to drug resistance, notably against Bortezomib, a critical proteasome inhibitor.
Onur Ateş, Yağmur Kiraz
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Agricultural azole fungicides induce cross-resistance to medical antifungals in Candida tropicalis: a One Health perspective on antifungal resistance

Mycology
The human opportunistic fungal pathogen Candida tropicalis is widely distributed in natural environments. In recent decades, the prevalence of azole-resistant isolates has increased markedly in the Asia-Pacific and Latin America.
Shuaihu Li, Tianren Hu, Chao Li, Tianchen Tan, Haiqing Chu, Guanghua Huang   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Editorial: Multiple Herbicide-Resistant Weeds and Non-target Site Resistance Mechanisms: A Global Challenge for Food Production

Frontiers in Plant Science, 2021
Joel Torra, María Dolores Osuna, Aldo Merotto, Martin Vila-Aiub   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Corrigendum: Cross-resistance among sequential cancer therapeutics: An emerging issue

Frontiers in Oncology, 2022
Rossella Loria, Patrizia Vici, Francesca Sofia Di Lisa, Francesca Sofia Di Lisa, Silvia Soddu, Marcello Maugeri-Saccà, Giulia Bon   +6 more
doaj   +1 more source

Emergence of new resistances to Cydia pomonella Granulovirus: insights from 12 years of monitoring

Frontiers in Physiology
IntroductionCodling moth resistance to the granulosis virus CpGV, a widely adopted biological control agent in apple orchards poses a significant challenge for growers.
Myriam Siegwart, Sandrine Maugin, Léa Gingueneau, Samantha Besse   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Clinical characteristics, drug resistance profiles, and inflammatory cytokine signatures in newly treated versus retreated MDR/RR-TB patients: associations with treatment outcomes

Frontiers in Microbiology
BackgroundMultidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) poses a significant threat to global tuberculosis control. Understanding drug resistance profiles, immune signatures, and their associations with treatment outcomes is critical ...
Yiyan Song, Dawei Yu, Junchi Xu, Yunxia Zhai, Huafeng Song, Hui Chen, Jianping Zhang, Ping Xu, Fanghua Li   +8 more
doaj   +1 more source