Results 71 to 80 of about 21,407 (216)

Biocidal Agents Used for Disinfection Can Enhance Antibiotic Resistance in Gram-Negative Species

Antibiotics, 2018
Biocidal agents used for disinfection are usually not suspected to enhance cross-resistance to antibiotics. The aim of this review was therefore to evaluate the effect of 13 biocidal agents at sublethal concentrations on antibiotic resistance in Gram ...
Günter Kampf
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Convergent adaptive architectures linking chemoresistance and radioresistance in chemoradiotherapy: a systems-level perspective

Frontiers in Oncology
BackgroundChemoradiotherapy (CRT) remains a cornerstone of treatment for multiple solid malignancies; however, durable disease control is frequently limited by the emergence of resistance. While chemoresistance and radioresistance have traditionally been
Xudong Yi, Faqiao Song, Shinsuke Nagasawa, Syogo Imai, Hiroyuki Arimatsu, Teppei Yamaoka, Kenjiro Shibata, Ryuya Hayashida, Aoi Okuno, Tomo Urano, Haruto Takahashi, Zhaohua Chang, Anji Wang, Kaizhen Yang, Hengmao Zhang, Haobo Zhao, Junko Takahashi   +16 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Azole-Driven Cross-Resistance and Transporter Gene Expression in Malassezia Yeasts

Microorganisms
Malassezia are commensal lipid dependent yeasts which can cause opportunistic skin infection. Topical imidazole antifungals such as clotrimazole and ketoconazole are the frontline treatment.
Ying Zhou Soo, Shi Mun Lee, Thomas L. Dawson, Cheryl Leong   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Characterization of ALS Inhibitor Resistance in Alopecurus myosuroides: Primary Role of Trp574Leu and Secondary Contributions of Additional Mutations and Metabolism

Weed Technology
Blackgrass is a highly competitive weed in wheat fields and has increasingly evolved resistance to acetolactate synthase (ALS)-inhibiting herbicides. Ten field populations were screened, resulting in the selection of one highly resistant population (R-06)
Mujeeba Fida, Rui Cheng, Mengjie Wang, Xiaoshen Song, Hui Yao, Weitang Liu, Zhiwen Wu, Yaling Bi   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Aneuploidy underlies brefeldin A-induced antifungal drug resistance in Cryptococcus neoformans

Frontiers in Cellular and Infection Microbiology
Cryptococcus neoformans is at the top of the list of “most wanted” human pathogens. Only three classes of antifungal drugs are available for the treatment of cryptococcosis.
Zhi-hui Zhang, Liu-liu Sun, Bu-qing Fu, Jie Deng, Cheng-lin Jia, Ming-xing Miao, Feng Yang, Feng Yang, Yong-bing Cao, Tian-hua Yan   +9 more
doaj   +1 more source

Chlorantraniliprole selection, synergism and cross-resistance to various insecticides in tomato pinworm, Tuta absoluta (Meyrick) [PDF]

نامه انجمن حشره‌شناسی ایران
Tuta absoluta is an invasive polyphagous pest recently reported on tomato, brinjal, and potato in India. It has acquired resistance to many chemical insecticides under field control.
Ranganathan Muthusamy, Govindaraju Ramkumar, Ranjani Rajendran, Senthil Kumar Jeyaraj, Suguna Kasirajan, Nagendiran Madhi   +5 more
doaj   +1 more source