Results 101 to 110 of about 4,771,637 (376)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Role of feasibility and pilot studies in randomised controlled trials: a cross-sectional study

BMJ Open, 2018
Objectives To assess the value of pilot and feasibility studies to randomised controlled trials (RCTs) funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme.
A. Blatch-Jones, Wei Pek, E. Kirkpatrick, M. Ashton-Key   +3 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Characteristics of recreational substance consumption in night clubs in the Aburrá Valley

Revista Facultad Nacional de Salud Pública, 2011
Objective: to explore the demographic characteristics and the features of “recreational substance” consumption in people attending night clubs located in some of the municipalities of the Aburrá Valley.
Gloria I. Martínez D, Lina M. Martínez S, María A. Rodríguez G, Cristian C. Benítez R, Catalina Franco R   +4 more
doaj  

Association between family structure, maternal education level, and maternal employment with sedentary lifestyle in primary school-age children

Jornal de Pediatria (Versão em Português), 2013
Objective: : To determine the association between family structure, maternal education level, and maternal employment with sedentary lifestyle in primary school-age children. Method: : Data were obtained from 897 children aged 6 to 12 years.
Francisco Vázquez-Nava, Norberto Treviño-Garcia-Manzo, Carlos F. Vázquez-Rodríguez, Eliza M. Vázquez-Rodríguez   +3 more
doaj   +1 more source

A Nonlinear Panel Data Model of Cross-Sectional Dependence [PDF]

This paper proposes a nonlinear panel data model which can generate endogenously both `weak' and `strong' cross-sectional dependence. The model's distinguishing characteristic is that a given agent's behaviour is influenced by an aggregation of the views
George Kapetanios, James Mitchell, Yongcheol Shin   +2 more
core  

Self-determination theory and diminished functioning: the role of interpersonal control and psychological need thwarting [PDF]

, 2011
Drawing from self-determination theory (Ryan & Deci, 2002), three studies explored the social-environmental conditions that satisfy versus thwart psychological needs and, in turn, impact psychological functioning and well/ill-being.
Bartholomew, Kimberley, Bosch, J., Ntoumanis, Nikos, Ryan, Richard M, Thøgersen-Ntoumani, Cecilie   +4 more
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Breakfast skipping and associated factors among Jordanian university students

Iranian Journal of Nursing and Midwifery Research
Background: Although breakfast skipping among university students is a significant concern, its prevalence and the contributing factors among university students have received little attention in the literature.
Enas Alshdifat, Abdullah Alkhawaldeh, Mohammed Albashtawy, Wafa'a Ta'an, Khitam Mohammad, Sami Al-Rawashdeh, Malakeh Malak, Hanan Al-Modallal, Tariq Al-Dwaikat, Ma'en Aljezawi, Shereen Hamadneh, Mohammad Suliman, Asem Abdalrahim, Sa'd Albashtawy   +13 more
doaj   +1 more source