Results 211 to 220 of about 70,257 (224)

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

Nature, 2017
The spreading of pathology within and between brain areas is a hallmark of neurodegenerative disorders. In patients with Alzheimer's disease, deposition of amyloid-β is accompanied by activation of the innate immune system and involves inflammasome-dependent formation of ASC specks in microglia.
Venegas, C., Kumar, S., Franklin, B., Dierkes, T., Brinkschulte, R., Tejera, D., Vieira-Saecker, A., Schwartz, S., Santarelli, F., Kummer, M., Griep, A., Gelpi, E., Beilharz, M., Riedel, D., Golenbock, D., Geyer, M., Walter, J., Latz, E., Heneka, M.   +18 more
openaire   +3 more sources

Seeding and Cross-seeding in Amyloid Diseases

2013
Seeding is a key phenomenon in all forms of amyloid and is most likely the mechanism by which amyloid deposits spread in a tissue and, in the case of systemic amyloidosis, from one organ to another. In experimental models of amyloid A (AA) amyloidosis, in which the fibril protein is derived from the acute phase reactant protein serum amyloid A (SAA ...
Per Westermark, Gunilla T. Westermark
openaire   +1 more source

Cross-Seeding of Amyloid-β in an Optically Controlled Thermophoretic Trap

Biophotonics Congress 2021, 2021
Processes such as secondary nucleation or fragmentation play a fundamental role in the formation and growth of amyloid fibrils. Here, we show that under physiological conditions those usually rare events occur nearly certain.
B. Fanselow, F. Hartmann, M. Zschocke, T. Thalheim, J. Adler, D. Huster, F. Cichos   +6 more
openaire   +1 more source

Cross-Seeding Interaction between β-Amyloid and Human Islet Amyloid Polypeptide

ACS Chemical Neuroscience, 2015
Alzheimer's disease (AD) and type 2 diabetes (T2D) are two common protein misfolding diseases. Increasing evidence suggests that these two diseases may be correlated with each other via cross-sequence interactions between β-amyloid peptide (Aβ) associated with AD and human islet amyloid polypeptide (hIAPP) associated with T2D.
Rundong, Hu, Mingzhen, Zhang, Hong, Chen, Binbo, Jiang, Jie, Zheng   +4 more
openaire   +2 more sources

Amyloid cross-seeding raises new dimensions to understanding of amyloidogenesis mechanism

Ageing Research Reviews, 2019
Hallmarks of most of the amyloid pathologies are surprisingly found to be heterocomponent entities such as inclusions and plaques which contain diverse essential proteins and metabolites. Experimental studies have already revealed the occurrence of coaggregation and cross-seeding during amyloid formation of several proteins and peptides, yielding ...
Paramita, Chaudhuri, Kailash P, Prajapati, Bibin G, Anand, Kriti, Dubey, Karunakar, Kar   +4 more
openaire   +2 more sources

Molecular Understanding of Aβ-hIAPP Cross-Seeding Assemblies on Lipid Membranes

ACS Chemical Neuroscience, 2016
Amyloid-β (Aβ) and human islet polypeptide (hIAPP) are the causative agents responsible for Alzheimer's disease (AD) and type II diabetes (T2D), respectively. While numerous studies have reported the cross-seeding behavior of Aβ and hIAPP in solution, little effort has been made to examine the cross-seeding of Aβ and hIAPP in the presence of cell ...
Mingzhen Zhang, Rundong Hu, Baiping Ren, Hong Chen, Binbo Jiang, Jie Ma, Jie Zheng   +6 more
openaire   +2 more sources

DESERT ROSE DIALLEL CROSSES: SEED PRODUCTION AND PHYSIOLOGY

Revista Contemporânea
The desert rose, known for its striking sculptural appearance and diverse flowers, holds a prominent place in the market. Despite its ornamental potential, there is limited information on the genetic variability and selection of superior genotypes and their seeds.
Andrea dos Santos Oliveira, Tanismare Tatiana de Almeida, Tales de Souza dos Santos, Cláudio das Neves Vieira Bárbara, Renata Silva-Mann   +4 more
openaire   +1 more source

Cross-Seeding Assay in the Investigation of the Amyloid Core of Prion Fibrils

2022
Amyloidogenesis, self-propagation of protein or peptide monomers to amyloid fibrils, has been linked to incurable pathogenesis of neurodegenerative diseases such as Alzheimer's disease and prion diseases. Investigations of amyloid structures and how monomers are transformed through seeding are therefore crucial for developing therapeutics toward these ...
Brett K-Y, Chu, Yu-Sheng, Lin, Howard C-H, Shen, Rita P-Y, Chen   +3 more
openaire   +2 more sources

Cross-Seeding Schemes for WDM-Based Next-Generation Optical Access Networks

Journal of Lightwave Technology, 2011
Rayleigh backscattering (RB) and Fresnel reflection (FR) effects can cause severe degradation on the performance of a WDM-PON system utilizing loop-back schemes that provide colorless upstream transmitters. We proposed cross-seeding schemes to overcome these problems and also to improve the utilization efficiency of the seeding lights.
Lin, S.C., Lee, S.L., Lin, H.H., Keiser, G., Ram, R.J.   +4 more
openaire   +2 more sources

Cross-Seeding of Fibrils from Two Types of Insulin Induces New Amyloid Strains

Biochemistry, 2012
The irreversibility and autocatalytic character of amyloidogenesis and the polymorphism of amyloid fibrils underlie the phenomenon of self-propagating strains, wherein the mother seed, rather than the seeding environment, determines the properties of daughter fibrils.
Weronika, Surmacz-Chwedoruk, Hanna, Nieznańska, Sławomir, Wójcik, Wojciech, Dzwolak   +3 more
openaire   +2 more sources