P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease
Acta Neuropathologica Communications, 2020 The transcription factor, p53, is critical for many important cellular functions involved in genome integrity, including cell cycle control, DNA damage response, and apoptosis.
Kathleen M. Farmer +5 more
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Structure-based inhibitors of amyloid beta core suggest a common interface with tau
eLife, 2019 Alzheimer’s disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau tangles which ...
Sarah L Griner +13 more
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Experimental observations and modelling of radiation asymmetries during N2 seeding in LHD
Nuclear Materials and Energy, 2021 N2 gas has been seeded in the Large Helical Device (LHD) to reduce the divertor heat load through enhanced radiation. Radiation is observed by two imaging bolometers, viewing the same poloidal cross-section from top and bottom ports, at a location which ...
B.J. Peterson +16 more
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Cross‐seeding effects of amyloid β‐protein and α‐synuclein [PDF]
Journal of Neurochemistry, 2012 J. Neurochem. (2012) 122, 883–890.AbstractAmyloid β‐protein (Aβ) and α‐synuclein (αS) are the primary components of amyloid plaques and Lewy bodies (LBs), respectively. Previous in vitro and in vivo studies have suggested that interactions between Aβ and αS are involved in the pathogenesis of Alzheimer’s disease and LB diseases.
Kenjiro, Ono +3 more
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LABORATORY TESTS OF A FOUR-SECTION SEED WHEEL WITH GROOVES IN THE SHAPE OF A PART OF THE ROTATION SURFACE OF A TORUS [PDF]
Volga Region Farmland, 2020 The article deals with the issue of improving the quality indicator of sowing cereal seeds, such as instability of total sowing and the results of laboratory research of experimental sowing machine, the reel of which is made four-sectional, with grooves ...
N.P. Laryushin +3 more
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Aβ Seeding as a Tool to Study Cerebral Amyloidosis and Associated Pathology
Frontiers in Molecular Neuroscience, 2019 Misfolded proteins can form aggregates and induce a self-perpetuating process leading to the amplification and spreading of pathological protein assemblies. These misfolded protein assemblies act as seeds of aggregation.
Marina Friesen +5 more
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Nature of cross-seeding barriers of amyloidogenesis.
Acta Biochimica Polonica, 2012 The epidemics of bovine spongiform encephalopathy (BSE) several decades ago and present epidemics of chronic wasting disease (CWD) among cervids posed a threat of cross-species infections to humans or other animals. Therefore, the question as to the molecular nature of the species barriers to transmissibility of prion diseases is very important.
Dariusz, Stępkowski, Juliusz, Bieniaś
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Q-Rich Yeast Prion [PSI+] Accelerates Aggregation of Transthyretin, a Non-Q-Rich Human Protein
Frontiers in Molecular Neuroscience, 2018 Interactions amongst different amyloid proteins have been proposed as a probable mechanism of aggregation and thus an important risk factor for the onset as well as progression of various neurodegenerative disorders including Alzheimer's, Parkinson's ...
Meenakshi Verma +6 more
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Cross-Species and Cross-Polymorph Seeding of Lysozyme Amyloid Reveals a Dominant Polymorph
Frontiers in Molecular Biosciences, 2020 The ability to self-propagate is one of the most intriguing characteristics of amyloid fibrils, and is a feature of great interest both to stopping unwanted pathological amyloid, and for engineering functional amyloid as a useful nanomaterial.
Lida Rahimi Araghi, Derek R. Dee
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Bone serves as a transfer station for secondary dissemination of breast cancer
Bone Research, 2023 Metastasis is responsible for the majority of deaths among breast cancer patients. Although parallel polyclonal seeding has been shown to contribute to organ-specific metastasis, in the past decade, horizontal cross-metastatic seeding (metastasis-to ...
Yufan Huang +3 more
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