Results 61 to 70 of about 70,257 (224)
Determination of seeding cycle by stem analysis of three beech stands [PDF]
تحقیقات جنگل و صنوبر ایران, 2005 Three natural stands of beech (Fagus orientalis Lipsky) at different parts of Caspian Forests of Iran (Kelardasht, Sangdeh and Gorgan) were chosen to determine their seeding cycle by stem analysis.
Ali Reza Mirbadin, Manoochehr Namiranian
doaj
Cholesterol determines the cytosolic entry and seeded aggregation of tau
Cell Reports, 2022 Summary: Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner. To accomplish this, tau must cross cell-limiting membranes, a process that is poorly understood. Here, we establish assays for the study of tau entry into
Benjamin J. Tuck +12 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Journal of Parkinson’s Disease, 2020 There is growing recognition in the field of neurodegenerative diseases that mixed proteinopathies are occurring at greater frequency than originally thought.
Rakez Kayed +2 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Nuclear Materials and Energy, 2018 Total deuterium (D) retention from the bulk material of reduced-activation ferritic-martensitic (RAFM) steel Eurofer’97 (EU’97) and commercial ferritic-martensitic grade P92 was traced experimentally by means of thermal desorption spectroscopy (TDS) and ...
Y. Martynova +10 more
doaj +1 more source
Myogenic commitment of human stem cells by myoblasts Co-culture: a static vs. a dynamic approach
Artificial Cells, Nanomedicine, and Biotechnology, 2022 An in-vitro model of human bone marrow mesenchymal stem cells (hBM-MSCs) myogenic commitment by synergic effect of a differentiation media coupled with human primary skeletal myoblasts (hSkMs) co-culture was developed adopting both conventional static co-
Pasqualina Scala +9 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Polymorphism of amyloid-like fibrils can be defined by the concentration of seeds [PDF]
PeerJ, 2015 Prions are infectious proteins where the same protein may express distinct strains. The strains are enciphered by different misfolded conformations. Strain-like phenomena have also been reported in a number of other amyloid-forming proteins.
Tomas Sneideris +2 more
doaj +2 more sources