Results 61 to 70 of about 3,494,819 (252)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Psychiatry and Behavioral Sciences, 2012 Objective: Type D personality, which is defined by both negative affectivity (NA) and social inhibition (SI), is associated with adverse outcomes in cardiac patients. The validity and reliability of the Type D Scale (DS_14) have been confirmed in various
Aytekin Alcelik +5 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 1957 Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Copy of original drawing. "Greetings at Christmas 1957 From Stan and Jess Cross and Stephen"; Also available in an electronic version via the internet at: http://nla.gov.au/nla.pic ...
Cross, Stan, 1888-1977.
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Journal of Sensor and Actuator NetworksThe reliance on fossil fuels as a primary global energy source has significantly impacted the environment, contributing to pollution and climate change. A shift towards renewable energy sources, particularly solar power, is underway, though these sources
Ray Colucci, Imad Mahgoub
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Reduction of decision rule of multivariate interpolation and approximation method in the problem of data classification [PDF]
Компьютерные исследования и моделирование, 2016 This article explores a method of machine learning based on the theory of random functions. One of the main problems of this method is that decision rule of a model becomes more complicated as the number of training dataset examples increases.
Ivan Vladimirovich Kopylov
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Cross-validation results (AUROC) of the non-GBT baseline models using 10-fold cross-validation.
, 2022 Cross-validation results (AUROC) of the non-GBT baseline models using 10-fold cross-validation.
Shaodong Wang (8825291) +7 more
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Unsupervised learning of nanoindentation data to infer microstructural details of complex materials
Frontiers in MaterialsIn this study, Cu-Cr composites were studied by nanoindentation. Arrays of indents were placed over large areas of the samples resulting in datasets consisting of several hundred measurements of Young’s modulus and hardness at varying indentation depths.
Chen Zhang +5 more
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