Results 111 to 120 of about 13,884,348 (293)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Beyond the Sacrificial Fantasy: Body, Law, and Desire

Open Theology
From its origins, the Christian religious imaginary has been inhabited by the sacrificial fantasy, which finds its most radical symbol in the crucified body.
Guanzini Isabella
doaj   +1 more source

The duration of foreclosures in the subprime mortgage market: a competing risks model with mixing [PDF]

This paper examines what happens to mortgages in the subprime mortgage market once foreclosure proceeding are initiated. A multinominial logit model that allows for the interdependence of the possible outcomes or risks (cure, partial cure, paid off, and ...
Anthony Pennington-Cross
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

OSMANLI’DA İNANÇ ALGISINDAKİ DÖNÜŞÜM BAĞLAMINDA HAÇ SEMBOLÜNE KARŞI TOPLUMSAL YAKLAŞIM

Türk Kültürü ve Hacı Bektaş Velî Araştırma Dergisi
18. yüzyıl ile belirginleşen gerileme sürecine koşut olarak alınan askeri yenilgiler veekonomik buhranları bu yüzyılın sonunda gerçekleşen Fransız İhtilali takip etti.
Burak Altunsoy
doaj   +1 more source

The use, role and reception of open badges as a method for formative and summative reward in two Massive Open Online Courses [PDF]

, 2014
Open online learning courses such as cMOOCs and xMOOCs differ from conventional courses yet it remains uncertain how, and if, existing common yet costly practices associated with teacher-driven formative and summative assessment strategies can be made to
Cross, Simon, Galley, Rebecca, Whitelock, Denise   +2 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Erken Dönem Hıristiyan Sinemasında Katolik Kilisesinin Etkisi

Medya ve Din Araştırmaları Dergisi
Katolik Kilisesi, sinemanın halktan gördüğü ilgiyi ve devlet adamları tarafından bir propaganda aracı olarak kullanıldığını erken dönemlerde fark eden ilk dini topluluktur. Bu doğrultuda Papa XI.
Yasin Öner
doaj   +1 more source