Results 61 to 70 of about 251,458 (268)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Cross-Border Cooperation: Subverting Sovereignty?

open access: yes, 2018
Work on European spatial planning has led me to criticise what I call territorialism.It conceives of the world in terms of a seamless cover of sovereign stateslooking after its territory each as if it were its property.
Faludi, A.K.F. (author)
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Sustaining cross-border cooperation : a cross-sectoral case study approach

open access: yes, 2006
Revised version of a paper presented at the final conference of the Mapping frontiers, plotting pathways: routes to North-South cooperation in a divided island programme, City Hotel, Armagh, 19-20 January 2006This paper is based on a set of case studies ...
O'Dowd, Liam   +2 more
core  

Trends and regional patterns of cross-border mergers and acquisitions: A case of Malaysian and Indonesian acquirers [PDF]

open access: yes, 2012
Progress of cross-border mergers and acquisitions (M&A) in Asian region demonstrates an upstream pattern although the economy in Europe is unhealthy.In fact, many cross-border deals in Europe are dominated by Asian and US acquirers.In 2010, Asia Pacific
Jedin, Mohd. Haniff
core  

DigitalGeographyLab/functional-cross-border-regions-nordics: v1.0

open access: yes, 2022
This repo contains code used in the article "The effect of COVID-19 on cross-border mobilities of people and functional border regions: the Nordic case study from Twitter data"
Olle Järv, Håvard Wallin Aagesen
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Cross-border e-commerce in Scandinavia: opportunities & challenges

open access: yes, 2021
The Scandinavian e-commerce market is growing exponentially. Denmark, Norway, and Sweden were all ranked in the top 10 of cross-border countries. This is an annual ranking of the best 16 European countries in cross-border online shopping by CBCommerce ...
Lone, Sara   +2 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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